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Electrical stimulation to treat tinnitus: a meta-analysis and systemic review of randomized controlled trials

BACKGROUND AND AIMS: Tinnitus is one of the most common otological symptoms that patients experience, and it can be debilitating. No effective drug treatments are available for tinnitus, although considerable research investigating its mechanisms and possible treatments is underway. Electrical stimu...

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Autores principales: Yang, Ting, Zhang, Jin, Wang, Bing, Zhang, Wen, Xu, Min, Yang, Shuangyuan, Liu, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442493/
https://www.ncbi.nlm.nih.gov/pubmed/34729140
http://dx.doi.org/10.1177/20406223211041069
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author Yang, Ting
Zhang, Jin
Wang, Bing
Zhang, Wen
Xu, Min
Yang, Shuangyuan
Liu, Hui
author_facet Yang, Ting
Zhang, Jin
Wang, Bing
Zhang, Wen
Xu, Min
Yang, Shuangyuan
Liu, Hui
author_sort Yang, Ting
collection PubMed
description BACKGROUND AND AIMS: Tinnitus is one of the most common otological symptoms that patients experience, and it can be debilitating. No effective drug treatments are available for tinnitus, although considerable research investigating its mechanisms and possible treatments is underway. Electrical stimulation has been considered a promising and well-tolerated therapeutic strategy for tinnitus. This meta-analysis study was aimed to investigate the efficacy, safety and tolerability of electrical stimulation in patients with tinnitus. METHODS: Relevant studies were retrieved from the Embase, PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature (CBM), Wanfang and Weipu databases. The Tinnitus Handicap Inventory (THI) and the visual analogue scale (VAS) which focus on loudness and distress evaluation (0–10 points) were used to assess perceived tinnitus suppression after treatment. Subgroup analysis was also performed based on different stimulating areas and methods, follow-up times, tinnitus duration and electrical current intensity. Review Manager 5.4 software was used for data synthesis, and Stata 15.1 software was used for analyses of publication bias and sensitivity. RESULTS: Our meta-analysis included 11 studies involving a total of 447 patients with tinnitus. The results showed that electrical stimulation significantly reduced THI scores [mean difference (MD) = −9.69; 95% confidence interval (CI) = −14.25, −5.13; p < 0.0001; I(2) = 80%] and VAS scores between the two groups (VAS loudness scores, MD = −0.72; 95% CI = −1.20, −0.25; VAS distress scores, MD = −0.90; 95% CI = −1.17, −0.63). In addition, subgroup analysis showed that THI scores in electrical stimulation group of different stimulating areas and methods follow-up times, tinnitus duration and electrical current intensity were generally reduced, regardless of the acute or subacute tinnitus group or left temporoparietal area (LTA) group with no statistical significance between two groups. CONCLUSION: Overall, electrical stimulation may be an effective and well-tolerated treatment option for tinnitus.
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spelling pubmed-84424932021-11-01 Electrical stimulation to treat tinnitus: a meta-analysis and systemic review of randomized controlled trials Yang, Ting Zhang, Jin Wang, Bing Zhang, Wen Xu, Min Yang, Shuangyuan Liu, Hui Ther Adv Chronic Dis Meta-Analysis BACKGROUND AND AIMS: Tinnitus is one of the most common otological symptoms that patients experience, and it can be debilitating. No effective drug treatments are available for tinnitus, although considerable research investigating its mechanisms and possible treatments is underway. Electrical stimulation has been considered a promising and well-tolerated therapeutic strategy for tinnitus. This meta-analysis study was aimed to investigate the efficacy, safety and tolerability of electrical stimulation in patients with tinnitus. METHODS: Relevant studies were retrieved from the Embase, PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature (CBM), Wanfang and Weipu databases. The Tinnitus Handicap Inventory (THI) and the visual analogue scale (VAS) which focus on loudness and distress evaluation (0–10 points) were used to assess perceived tinnitus suppression after treatment. Subgroup analysis was also performed based on different stimulating areas and methods, follow-up times, tinnitus duration and electrical current intensity. Review Manager 5.4 software was used for data synthesis, and Stata 15.1 software was used for analyses of publication bias and sensitivity. RESULTS: Our meta-analysis included 11 studies involving a total of 447 patients with tinnitus. The results showed that electrical stimulation significantly reduced THI scores [mean difference (MD) = −9.69; 95% confidence interval (CI) = −14.25, −5.13; p < 0.0001; I(2) = 80%] and VAS scores between the two groups (VAS loudness scores, MD = −0.72; 95% CI = −1.20, −0.25; VAS distress scores, MD = −0.90; 95% CI = −1.17, −0.63). In addition, subgroup analysis showed that THI scores in electrical stimulation group of different stimulating areas and methods follow-up times, tinnitus duration and electrical current intensity were generally reduced, regardless of the acute or subacute tinnitus group or left temporoparietal area (LTA) group with no statistical significance between two groups. CONCLUSION: Overall, electrical stimulation may be an effective and well-tolerated treatment option for tinnitus. SAGE Publications 2021-09-13 /pmc/articles/PMC8442493/ /pubmed/34729140 http://dx.doi.org/10.1177/20406223211041069 Text en © The Author(s), 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Meta-Analysis
Yang, Ting
Zhang, Jin
Wang, Bing
Zhang, Wen
Xu, Min
Yang, Shuangyuan
Liu, Hui
Electrical stimulation to treat tinnitus: a meta-analysis and systemic review of randomized controlled trials
title Electrical stimulation to treat tinnitus: a meta-analysis and systemic review of randomized controlled trials
title_full Electrical stimulation to treat tinnitus: a meta-analysis and systemic review of randomized controlled trials
title_fullStr Electrical stimulation to treat tinnitus: a meta-analysis and systemic review of randomized controlled trials
title_full_unstemmed Electrical stimulation to treat tinnitus: a meta-analysis and systemic review of randomized controlled trials
title_short Electrical stimulation to treat tinnitus: a meta-analysis and systemic review of randomized controlled trials
title_sort electrical stimulation to treat tinnitus: a meta-analysis and systemic review of randomized controlled trials
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442493/
https://www.ncbi.nlm.nih.gov/pubmed/34729140
http://dx.doi.org/10.1177/20406223211041069
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