Cargando…

Portable air-fed cold atmospheric plasma device for postsurgical cancer treatment

Surgery represents the major option for treating most solid tumors. Despite continuous improvements in surgical techniques, cancer recurrence after surgical resection remains the most common cause of treatment failure. Here, we report cold atmospheric plasma (CAP)–mediated postsurgical cancer treatm...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Guojun, Chen, Zhitong, Wang, Zejun, Obenchain, Richard, Wen, Di, Li, Hongjun, Wirz, Richard E., Gu, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442862/
https://www.ncbi.nlm.nih.gov/pubmed/34516919
http://dx.doi.org/10.1126/sciadv.abg5686
_version_ 1783753080072830976
author Chen, Guojun
Chen, Zhitong
Wang, Zejun
Obenchain, Richard
Wen, Di
Li, Hongjun
Wirz, Richard E.
Gu, Zhen
author_facet Chen, Guojun
Chen, Zhitong
Wang, Zejun
Obenchain, Richard
Wen, Di
Li, Hongjun
Wirz, Richard E.
Gu, Zhen
author_sort Chen, Guojun
collection PubMed
description Surgery represents the major option for treating most solid tumors. Despite continuous improvements in surgical techniques, cancer recurrence after surgical resection remains the most common cause of treatment failure. Here, we report cold atmospheric plasma (CAP)–mediated postsurgical cancer treatment, using a portable air-fed CAP (aCAP) device. The aCAP device we developed uses the local ambient air as the source gas to generate cold plasma discharge with only joule energy level electrical input, thus providing a device that is simple and highly tunable for a wide range of biomedical applications. We demonstrate that local aCAP treatment on residual tumor cells at the surgical cavities effectively induces cancer immunogenic cell death in situ and evokes strong T cell–mediated immune responses to combat the residual tumor cells. In both 4T1 breast tumor and B16F10 melanoma models, aCAP treatment after incomplete tumor resection contributes to inhibiting tumor growth and prolonging survival.
format Online
Article
Text
id pubmed-8442862
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher American Association for the Advancement of Science
record_format MEDLINE/PubMed
spelling pubmed-84428622021-09-24 Portable air-fed cold atmospheric plasma device for postsurgical cancer treatment Chen, Guojun Chen, Zhitong Wang, Zejun Obenchain, Richard Wen, Di Li, Hongjun Wirz, Richard E. Gu, Zhen Sci Adv Physical and Materials Sciences Surgery represents the major option for treating most solid tumors. Despite continuous improvements in surgical techniques, cancer recurrence after surgical resection remains the most common cause of treatment failure. Here, we report cold atmospheric plasma (CAP)–mediated postsurgical cancer treatment, using a portable air-fed CAP (aCAP) device. The aCAP device we developed uses the local ambient air as the source gas to generate cold plasma discharge with only joule energy level electrical input, thus providing a device that is simple and highly tunable for a wide range of biomedical applications. We demonstrate that local aCAP treatment on residual tumor cells at the surgical cavities effectively induces cancer immunogenic cell death in situ and evokes strong T cell–mediated immune responses to combat the residual tumor cells. In both 4T1 breast tumor and B16F10 melanoma models, aCAP treatment after incomplete tumor resection contributes to inhibiting tumor growth and prolonging survival. American Association for the Advancement of Science 2021-09-01 /pmc/articles/PMC8442862/ /pubmed/34516919 http://dx.doi.org/10.1126/sciadv.abg5686 Text en Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Physical and Materials Sciences
Chen, Guojun
Chen, Zhitong
Wang, Zejun
Obenchain, Richard
Wen, Di
Li, Hongjun
Wirz, Richard E.
Gu, Zhen
Portable air-fed cold atmospheric plasma device for postsurgical cancer treatment
title Portable air-fed cold atmospheric plasma device for postsurgical cancer treatment
title_full Portable air-fed cold atmospheric plasma device for postsurgical cancer treatment
title_fullStr Portable air-fed cold atmospheric plasma device for postsurgical cancer treatment
title_full_unstemmed Portable air-fed cold atmospheric plasma device for postsurgical cancer treatment
title_short Portable air-fed cold atmospheric plasma device for postsurgical cancer treatment
title_sort portable air-fed cold atmospheric plasma device for postsurgical cancer treatment
topic Physical and Materials Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442862/
https://www.ncbi.nlm.nih.gov/pubmed/34516919
http://dx.doi.org/10.1126/sciadv.abg5686
work_keys_str_mv AT chenguojun portableairfedcoldatmosphericplasmadeviceforpostsurgicalcancertreatment
AT chenzhitong portableairfedcoldatmosphericplasmadeviceforpostsurgicalcancertreatment
AT wangzejun portableairfedcoldatmosphericplasmadeviceforpostsurgicalcancertreatment
AT obenchainrichard portableairfedcoldatmosphericplasmadeviceforpostsurgicalcancertreatment
AT wendi portableairfedcoldatmosphericplasmadeviceforpostsurgicalcancertreatment
AT lihongjun portableairfedcoldatmosphericplasmadeviceforpostsurgicalcancertreatment
AT wirzricharde portableairfedcoldatmosphericplasmadeviceforpostsurgicalcancertreatment
AT guzhen portableairfedcoldatmosphericplasmadeviceforpostsurgicalcancertreatment