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Portable air-fed cold atmospheric plasma device for postsurgical cancer treatment
Surgery represents the major option for treating most solid tumors. Despite continuous improvements in surgical techniques, cancer recurrence after surgical resection remains the most common cause of treatment failure. Here, we report cold atmospheric plasma (CAP)–mediated postsurgical cancer treatm...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442862/ https://www.ncbi.nlm.nih.gov/pubmed/34516919 http://dx.doi.org/10.1126/sciadv.abg5686 |
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author | Chen, Guojun Chen, Zhitong Wang, Zejun Obenchain, Richard Wen, Di Li, Hongjun Wirz, Richard E. Gu, Zhen |
author_facet | Chen, Guojun Chen, Zhitong Wang, Zejun Obenchain, Richard Wen, Di Li, Hongjun Wirz, Richard E. Gu, Zhen |
author_sort | Chen, Guojun |
collection | PubMed |
description | Surgery represents the major option for treating most solid tumors. Despite continuous improvements in surgical techniques, cancer recurrence after surgical resection remains the most common cause of treatment failure. Here, we report cold atmospheric plasma (CAP)–mediated postsurgical cancer treatment, using a portable air-fed CAP (aCAP) device. The aCAP device we developed uses the local ambient air as the source gas to generate cold plasma discharge with only joule energy level electrical input, thus providing a device that is simple and highly tunable for a wide range of biomedical applications. We demonstrate that local aCAP treatment on residual tumor cells at the surgical cavities effectively induces cancer immunogenic cell death in situ and evokes strong T cell–mediated immune responses to combat the residual tumor cells. In both 4T1 breast tumor and B16F10 melanoma models, aCAP treatment after incomplete tumor resection contributes to inhibiting tumor growth and prolonging survival. |
format | Online Article Text |
id | pubmed-8442862 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-84428622021-09-24 Portable air-fed cold atmospheric plasma device for postsurgical cancer treatment Chen, Guojun Chen, Zhitong Wang, Zejun Obenchain, Richard Wen, Di Li, Hongjun Wirz, Richard E. Gu, Zhen Sci Adv Physical and Materials Sciences Surgery represents the major option for treating most solid tumors. Despite continuous improvements in surgical techniques, cancer recurrence after surgical resection remains the most common cause of treatment failure. Here, we report cold atmospheric plasma (CAP)–mediated postsurgical cancer treatment, using a portable air-fed CAP (aCAP) device. The aCAP device we developed uses the local ambient air as the source gas to generate cold plasma discharge with only joule energy level electrical input, thus providing a device that is simple and highly tunable for a wide range of biomedical applications. We demonstrate that local aCAP treatment on residual tumor cells at the surgical cavities effectively induces cancer immunogenic cell death in situ and evokes strong T cell–mediated immune responses to combat the residual tumor cells. In both 4T1 breast tumor and B16F10 melanoma models, aCAP treatment after incomplete tumor resection contributes to inhibiting tumor growth and prolonging survival. American Association for the Advancement of Science 2021-09-01 /pmc/articles/PMC8442862/ /pubmed/34516919 http://dx.doi.org/10.1126/sciadv.abg5686 Text en Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Physical and Materials Sciences Chen, Guojun Chen, Zhitong Wang, Zejun Obenchain, Richard Wen, Di Li, Hongjun Wirz, Richard E. Gu, Zhen Portable air-fed cold atmospheric plasma device for postsurgical cancer treatment |
title | Portable air-fed cold atmospheric plasma device for postsurgical cancer treatment |
title_full | Portable air-fed cold atmospheric plasma device for postsurgical cancer treatment |
title_fullStr | Portable air-fed cold atmospheric plasma device for postsurgical cancer treatment |
title_full_unstemmed | Portable air-fed cold atmospheric plasma device for postsurgical cancer treatment |
title_short | Portable air-fed cold atmospheric plasma device for postsurgical cancer treatment |
title_sort | portable air-fed cold atmospheric plasma device for postsurgical cancer treatment |
topic | Physical and Materials Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442862/ https://www.ncbi.nlm.nih.gov/pubmed/34516919 http://dx.doi.org/10.1126/sciadv.abg5686 |
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