Ameliorating the hallmarks of cellular senescence in skeletal muscle myogenic progenitors in vitro and in vivo

Senescence of myogenic progenitors impedes skeletal muscle regeneration. Here, we show that overexpression of the transcription factor NANOG in senescent myoblasts can overcome the effects of cellular senescence and confer a youthful phenotype to senescent cells. NANOG ameliorated primary hallmarks...

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Detalles Bibliográficos
Autores principales: Shahini, Aref, Rajabian, Nika, Choudhury, Debanik, Shahini, Shahryar, Vydiam, Kalyan, Nguyen, Thy, Kulczyk, Joseph, Santarelli, Tyler, Ikhapoh, Izuagie, Zhang, Yali, Wang, Jianmin, Liu, Song, Stablewski, Aimee, Thiyagarajan, Ramkumar, Seldeen, Kenneth, Troen, Bruce R., Peirick, Jennifer, Lei, Pedro, Andreadis, Stelios T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442867/
https://www.ncbi.nlm.nih.gov/pubmed/34516892
http://dx.doi.org/10.1126/sciadv.abe5671

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