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INTS11 regulates hematopoiesis by promoting PRC2 function

INTS11, the catalytic subunit of the Integrator (INT) complex, is crucial for the biogenesis of small nuclear RNAs and enhancer RNAs. However, the role of INTS11 in hematopoietic stem and progenitor cell (HSPC) biology is unknown. Here, we report that INTS11 is required for normal hematopoiesis and...

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Detalles Bibliográficos
Autores principales:	Zhang, Peng, Sui, Pinpin, Chen, Shi, Guo, Ying, Li, Ying, Ge, Guo, Zhu, Ganqian, Yang, Hui, Rogers, Cody M., Sung, Patrick, Nimer, Stephen D., Xu, Mingjiang, Yang, Feng-Chun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442872/ https://www.ncbi.nlm.nih.gov/pubmed/34516911 http://dx.doi.org/10.1126/sciadv.abh1684

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