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A genome-engineered bioartificial implant for autoregulated anticytokine drug delivery

Biologic drug therapies are increasingly used for inflammatory diseases such as rheumatoid arthritis but may cause significant adverse effects when delivered continuously at high doses. We used CRISPR-Cas9 genome editing of iPSCs to create a synthetic gene circuit that senses changing levels of endo...

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Detalles Bibliográficos
Autores principales:	Choi, Yun-Rak, Collins, Kelsey H., Springer, Luke E., Pferdehirt, Lara, Ross, Alison K., Wu, Chia-Lung, Moutos, Franklin T., Harasymowicz, Natalia S., Brunger, Jonathan M., Pham, Christine T. N., Guilak, Farshid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442875/ https://www.ncbi.nlm.nih.gov/pubmed/34516920 http://dx.doi.org/10.1126/sciadv.abj1414

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