Platelets amplify endotheliopathy in COVID-19

Given the evidence for a hyperactive platelet phenotype in COVID-19, we investigated effector cell properties of COVID-19 platelets on endothelial cells (ECs). Integration of EC and platelet RNA sequencing revealed that platelet-released factors in COVID-19 promote an inflammatory hypercoagulable en...

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Detalles Bibliográficos
Autores principales: Barrett, Tessa J., Cornwell, MacIntosh, Myndzar, Khrystyna, Rolling, Christina C., Xia, Yuhe, Drenkova, Kamelia, Biebuyck, Antoine, Fields, Alexander T., Tawil, Michael, Luttrell-Williams, Elliot, Yuriditsky, Eugene, Smith, Grace, Cotzia, Paolo, Neal, Matthew D., Kornblith, Lucy Z., Pittaluga, Stefania, Rapkiewicz, Amy V., Burgess, Hannah M., Mohr, Ian, Stapleford, Kenneth A., Voora, Deepak, Ruggles, Kelly, Hochman, Judith, Berger, Jeffrey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442885/
https://www.ncbi.nlm.nih.gov/pubmed/34516880
http://dx.doi.org/10.1126/sciadv.abh2434

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