Single-cell transcriptome of early hematopoiesis guides arterial endothelial-enhanced functional T cell generation from human PSCs

Hematopoietic differentiation of human pluripotent stem cells (hPSCs) requires orchestration of dynamic cell and gene regulatory networks but often generates blood cells that lack natural function. Here, we performed extensive single-cell transcriptomic analyses to map fate choices and gene expressi...

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Detalles Bibliográficos
Autores principales: Shen, Jun, Xu, Yingxi, Zhang, Shuo, Lyu, Shuzhen, Huo, Yingying, Zhu, Yaoyao, Tang, Kejing, Mou, Junli, Li, Xinjie, Hoyle, Dixie L., Wang, Min, Wang, Jianxiang, Li, Xin, Wang, Zack Z., Cheng, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442917/
https://www.ncbi.nlm.nih.gov/pubmed/34516916
http://dx.doi.org/10.1126/sciadv.abi9787

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