Podocyte-specific KLF4 is required to maintain parietal epithelial cell quiescence in the kidney

Podocyte loss triggering aberrant activation and proliferation of parietal epithelial cells (PECs) is a central pathogenic event in proliferative glomerulopathies. Podocyte-specific Krüppel-like factor 4 (KLF4), a zinc-finger transcription factor, is essential for maintaining podocyte homeostasis an...

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Detalles Bibliográficos
Autores principales: Pace, Jesse A., Bronstein, Robert, Guo, Yiqing, Yang, Yaqi, Estrada, Chelsea C., Gujarati, Nehaben, Salant, David J., Haley, John, Bialkowska, Agnieszka B., Yang, Vincent W., He, John C., Mallipattu, Sandeep K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442927/
https://www.ncbi.nlm.nih.gov/pubmed/34516901
http://dx.doi.org/10.1126/sciadv.abg6600

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