The Role of Exosomal miRNAs in Glioma: Biological Function and Clinical Application

Gliomas are complex and heterogeneous central nervous system tumors with poor prognosis. Despite the increasing development of aggressive combination therapies, the prognosis of glioma is generally unsatisfactory. Exosomal microRNA (miRNA) has been successfully used in other diseases as a reliable b...

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Autores principales: Aili, Yirizhati, Maimaitiming, Nuersimanguli, Mahemuti, Yusufu, Qin, Hu, Wang, Yongxin, Wang, Zengliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442992/
https://www.ncbi.nlm.nih.gov/pubmed/34540663
http://dx.doi.org/10.3389/fonc.2021.686369
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author Aili, Yirizhati
Maimaitiming, Nuersimanguli
Mahemuti, Yusufu
Qin, Hu
Wang, Yongxin
Wang, Zengliang
author_facet Aili, Yirizhati
Maimaitiming, Nuersimanguli
Mahemuti, Yusufu
Qin, Hu
Wang, Yongxin
Wang, Zengliang
author_sort Aili, Yirizhati
collection PubMed
description Gliomas are complex and heterogeneous central nervous system tumors with poor prognosis. Despite the increasing development of aggressive combination therapies, the prognosis of glioma is generally unsatisfactory. Exosomal microRNA (miRNA) has been successfully used in other diseases as a reliable biomarker and even therapeutic target. Recent studies show that exosomal miRNA plays an important role in glioma occurrence, development, invasion, metastasis, and treatment resistance. However, the association of exosomal miRNA between glioma has not been systemically characterized. This will provide a theoretical basis for us to further explore the relationship between exosomal miRNAs and glioma and also has a positive clinical significance in the innovative diagnosis and treatment of glioma.
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spelling pubmed-84429922021-09-16 The Role of Exosomal miRNAs in Glioma: Biological Function and Clinical Application Aili, Yirizhati Maimaitiming, Nuersimanguli Mahemuti, Yusufu Qin, Hu Wang, Yongxin Wang, Zengliang Front Oncol Oncology Gliomas are complex and heterogeneous central nervous system tumors with poor prognosis. Despite the increasing development of aggressive combination therapies, the prognosis of glioma is generally unsatisfactory. Exosomal microRNA (miRNA) has been successfully used in other diseases as a reliable biomarker and even therapeutic target. Recent studies show that exosomal miRNA plays an important role in glioma occurrence, development, invasion, metastasis, and treatment resistance. However, the association of exosomal miRNA between glioma has not been systemically characterized. This will provide a theoretical basis for us to further explore the relationship between exosomal miRNAs and glioma and also has a positive clinical significance in the innovative diagnosis and treatment of glioma. Frontiers Media S.A. 2021-09-01 /pmc/articles/PMC8442992/ /pubmed/34540663 http://dx.doi.org/10.3389/fonc.2021.686369 Text en Copyright © 2021 Aili, Maimaitiming, Mahemuti, Qin, Wang and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Aili, Yirizhati
Maimaitiming, Nuersimanguli
Mahemuti, Yusufu
Qin, Hu
Wang, Yongxin
Wang, Zengliang
The Role of Exosomal miRNAs in Glioma: Biological Function and Clinical Application
title The Role of Exosomal miRNAs in Glioma: Biological Function and Clinical Application
title_full The Role of Exosomal miRNAs in Glioma: Biological Function and Clinical Application
title_fullStr The Role of Exosomal miRNAs in Glioma: Biological Function and Clinical Application
title_full_unstemmed The Role of Exosomal miRNAs in Glioma: Biological Function and Clinical Application
title_short The Role of Exosomal miRNAs in Glioma: Biological Function and Clinical Application
title_sort role of exosomal mirnas in glioma: biological function and clinical application
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442992/
https://www.ncbi.nlm.nih.gov/pubmed/34540663
http://dx.doi.org/10.3389/fonc.2021.686369
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