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Dialyzer First Use Reaction with Polysulfone Membrane: Moving Beyond Ethylene Oxide

Acute anaphylactic/anaphylactoid reactions to dialyzers are uncommon. Indeed, they are thought to have decreased in incidence since the transition to more biocompatible dialyzer membranes and with the abandonment of ethylene oxide for sterilization of dialyzers. However, few recent Spanish studies s...

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Detalles Bibliográficos
Autor principal: Tharakan, Abraham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443108/
https://www.ncbi.nlm.nih.gov/pubmed/34584359
http://dx.doi.org/10.4103/ijn.IJN_231_20
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author Tharakan, Abraham
author_facet Tharakan, Abraham
author_sort Tharakan, Abraham
collection PubMed
description Acute anaphylactic/anaphylactoid reactions to dialyzers are uncommon. Indeed, they are thought to have decreased in incidence since the transition to more biocompatible dialyzer membranes and with the abandonment of ethylene oxide for sterilization of dialyzers. However, few recent Spanish studies suggest that the incidence actually remains the same. Here, we report two cases of dialyzer first use reactions that occurred with polysulfone dialyzers. These were not ethylene oxide sterilized dialyzers and the reactions were less intense/absent from the second reuse onwards. Both the patients were successfully dialyzed by switching to a cellulose triacetate dialyzer or by using a preprocessed dialyzer filled with renalin. Thus, the cause of the reaction could either be the primary polysulfone membrane or a leachable substance from the dialyzer.
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spelling pubmed-84431082021-09-27 Dialyzer First Use Reaction with Polysulfone Membrane: Moving Beyond Ethylene Oxide Tharakan, Abraham Indian J Nephrol Case Report Acute anaphylactic/anaphylactoid reactions to dialyzers are uncommon. Indeed, they are thought to have decreased in incidence since the transition to more biocompatible dialyzer membranes and with the abandonment of ethylene oxide for sterilization of dialyzers. However, few recent Spanish studies suggest that the incidence actually remains the same. Here, we report two cases of dialyzer first use reactions that occurred with polysulfone dialyzers. These were not ethylene oxide sterilized dialyzers and the reactions were less intense/absent from the second reuse onwards. Both the patients were successfully dialyzed by switching to a cellulose triacetate dialyzer or by using a preprocessed dialyzer filled with renalin. Thus, the cause of the reaction could either be the primary polysulfone membrane or a leachable substance from the dialyzer. Wolters Kluwer - Medknow 2021 2021-02-16 /pmc/articles/PMC8443108/ /pubmed/34584359 http://dx.doi.org/10.4103/ijn.IJN_231_20 Text en Copyright: © 2021 Indian Journal of Nephrology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Tharakan, Abraham
Dialyzer First Use Reaction with Polysulfone Membrane: Moving Beyond Ethylene Oxide
title Dialyzer First Use Reaction with Polysulfone Membrane: Moving Beyond Ethylene Oxide
title_full Dialyzer First Use Reaction with Polysulfone Membrane: Moving Beyond Ethylene Oxide
title_fullStr Dialyzer First Use Reaction with Polysulfone Membrane: Moving Beyond Ethylene Oxide
title_full_unstemmed Dialyzer First Use Reaction with Polysulfone Membrane: Moving Beyond Ethylene Oxide
title_short Dialyzer First Use Reaction with Polysulfone Membrane: Moving Beyond Ethylene Oxide
title_sort dialyzer first use reaction with polysulfone membrane: moving beyond ethylene oxide
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443108/
https://www.ncbi.nlm.nih.gov/pubmed/34584359
http://dx.doi.org/10.4103/ijn.IJN_231_20
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