NSG-Pro mouse model for uncovering resistance mechanisms and unique vulnerabilities in human luminal breast cancers

Most breast cancer deaths are caused by estrogen receptor-α–positive (ER(+)) disease. Preclinical progress is hampered by a shortage of therapy-naïve ER(+) tumor models that recapitulate metastatic progression and clinically relevant therapy resistance. Human prolactin (hPRL) is a risk factor for pr...

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Detalles Bibliográficos
Autores principales: Sun, Yunguang, Yang, Ning, Utama, Fransiscus E., Udhane, Sameer S., Zhang, Junling, Peck, Amy R., Yanac, Alicia, Duffey, Katherine, Langenheim, John F., Udhane, Vindhya, Xia, Guanjun, Peterson, Jess F., Jorns, Julie M., Nevalainen, Marja T., Rouet, Romain, Schofield, Peter, Christ, Daniel, Ormandy, Christopher J., Rosenberg, Anne L., Chervoneva, Inna, Tsaih, Shirng-Wern, Flister, Michael J., Fuchs, Serge Y., Wagner, Kay-Uwe, Rui, Hallgeir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443188/
https://www.ncbi.nlm.nih.gov/pubmed/34524841
http://dx.doi.org/10.1126/sciadv.abc8145

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