TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma

Fusion-transcription factors (fusion-TFs) represent a class of driver oncoproteins that are difficult to therapeutically target. Recently, protein degradation has emerged as a strategy to target these challenging oncoproteins. The mechanisms that regulate fusion-TF stability, however, are generally...

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Detalles Bibliográficos
Autores principales: Seong, Bo Kyung A., Dharia, Neekesh V., Lin, Shan, Donovan, Katherine A., Chong, Shasha, Robichaud, Amanda, Conway, Amy, Hamze, Amanda, Ross, Linda, Alexe, Gabriela, Adane, Biniam, Nabet, Behnam, Ferguson, Fleur M., Stolte, Björn, Wang, Emily Jue, Sun, Jialin, Darzacq, Xavier, Piccioni, Federica, Gray, Nathanael S., Fischer, Eric S., Stegmaier, Kimberly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443273/
https://www.ncbi.nlm.nih.gov/pubmed/34329586
http://dx.doi.org/10.1016/j.ccell.2021.07.003

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