Genetically variant human pluripotent stem cells selectively eliminate wild-type counterparts through YAP-mediated cell competition

The appearance of genetic changes in human pluripotent stem cells (hPSCs) presents a concern for their use in research and regenerative medicine. Variant hPSCs that harbor recurrent culture-acquired aneuploidies display growth advantages over wild-type diploid cells, but the mechanisms that yield a...

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Detalles Bibliográficos
Autores principales: Price, Christopher J., Stavish, Dylan, Gokhale, Paul J., Stevenson, Ben A., Sargeant, Samantha, Lacey, Joanne, Rodriguez, Tristan A., Barbaric, Ivana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443275/
https://www.ncbi.nlm.nih.gov/pubmed/34407428
http://dx.doi.org/10.1016/j.devcel.2021.07.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443275/
https://www.ncbi.nlm.nih.gov/pubmed/34407428
http://dx.doi.org/10.1016/j.devcel.2021.07.019

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