Reversal of Radiotherapy Resistance of Ovarian Cancer Cell Strain CAOV3/R by Targeting lncRNA CRNDE

Radiotherapy resistance is one of the key factors of poor prognosis of ovarian cancer clinical treatment. The search for key targets of ovarian cancer radiotherapy resistance has become a high priority. Long noncoding RNA plays an important role in tumor development. However, the key lncRNA in ovari...

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Detalles Bibliográficos
Autores principales: Yang, Wencui, Li, Xiaoning, Zhao, Lin, Zhao, Fengju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443391/
https://www.ncbi.nlm.nih.gov/pubmed/34540189
http://dx.doi.org/10.1155/2021/8556965
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author Yang, Wencui
Li, Xiaoning
Zhao, Lin
Zhao, Fengju
author_facet Yang, Wencui
Li, Xiaoning
Zhao, Lin
Zhao, Fengju
author_sort Yang, Wencui
collection PubMed
description Radiotherapy resistance is one of the key factors of poor prognosis of ovarian cancer clinical treatment. The search for key targets of ovarian cancer radiotherapy resistance has become a high priority. Long noncoding RNA plays an important role in tumor development. However, the key lncRNA in ovarian cancer radiotherapy resistance is not identified. Our finding that lncRNA CRNDE is highly expressed in the radiotherapy resistance cell line CAOV3/R drew our attention. Therefore, in this study, we targeted lncRNA CRNDE to analyze whether it is a key factor of radiotherapy resistance in ovarian cancer. Ultimately, we found that silencing lncRNA CRNDE could reverse CAOV3/R radiotherapy resistance, which would be a boon to clinical treatment.
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spelling pubmed-84433912021-09-16 Reversal of Radiotherapy Resistance of Ovarian Cancer Cell Strain CAOV3/R by Targeting lncRNA CRNDE Yang, Wencui Li, Xiaoning Zhao, Lin Zhao, Fengju J Healthc Eng Research Article Radiotherapy resistance is one of the key factors of poor prognosis of ovarian cancer clinical treatment. The search for key targets of ovarian cancer radiotherapy resistance has become a high priority. Long noncoding RNA plays an important role in tumor development. However, the key lncRNA in ovarian cancer radiotherapy resistance is not identified. Our finding that lncRNA CRNDE is highly expressed in the radiotherapy resistance cell line CAOV3/R drew our attention. Therefore, in this study, we targeted lncRNA CRNDE to analyze whether it is a key factor of radiotherapy resistance in ovarian cancer. Ultimately, we found that silencing lncRNA CRNDE could reverse CAOV3/R radiotherapy resistance, which would be a boon to clinical treatment. Hindawi 2021-09-08 /pmc/articles/PMC8443391/ /pubmed/34540189 http://dx.doi.org/10.1155/2021/8556965 Text en Copyright © 2021 Wencui Yang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yang, Wencui
Li, Xiaoning
Zhao, Lin
Zhao, Fengju
Reversal of Radiotherapy Resistance of Ovarian Cancer Cell Strain CAOV3/R by Targeting lncRNA CRNDE
title Reversal of Radiotherapy Resistance of Ovarian Cancer Cell Strain CAOV3/R by Targeting lncRNA CRNDE
title_full Reversal of Radiotherapy Resistance of Ovarian Cancer Cell Strain CAOV3/R by Targeting lncRNA CRNDE
title_fullStr Reversal of Radiotherapy Resistance of Ovarian Cancer Cell Strain CAOV3/R by Targeting lncRNA CRNDE
title_full_unstemmed Reversal of Radiotherapy Resistance of Ovarian Cancer Cell Strain CAOV3/R by Targeting lncRNA CRNDE
title_short Reversal of Radiotherapy Resistance of Ovarian Cancer Cell Strain CAOV3/R by Targeting lncRNA CRNDE
title_sort reversal of radiotherapy resistance of ovarian cancer cell strain caov3/r by targeting lncrna crnde
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443391/
https://www.ncbi.nlm.nih.gov/pubmed/34540189
http://dx.doi.org/10.1155/2021/8556965
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AT zhaolin reversalofradiotherapyresistanceofovariancancercellstraincaov3rbytargetinglncrnacrnde
AT zhaofengju reversalofradiotherapyresistanceofovariancancercellstraincaov3rbytargetinglncrnacrnde

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