The two facets of gp130 signalling in liver tumorigenesis

The liver is a vital organ with multiple functions and a large regenerative capacity. Tumours of the liver are the second most frequently cause of cancer-related death and develop in chronically inflamed livers. IL-6-type cytokines are mediators of inflammation and almost all members signal via the...

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Detalles Bibliográficos
Autores principales: Schmidt-Arras, Dirk, Galun, Eithan, Rose-John, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443519/
https://www.ncbi.nlm.nih.gov/pubmed/34047814
http://dx.doi.org/10.1007/s00281-021-00861-0
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author Schmidt-Arras, Dirk
Galun, Eithan
Rose-John, Stefan
author_facet Schmidt-Arras, Dirk
Galun, Eithan
Rose-John, Stefan
author_sort Schmidt-Arras, Dirk
collection PubMed
description The liver is a vital organ with multiple functions and a large regenerative capacity. Tumours of the liver are the second most frequently cause of cancer-related death and develop in chronically inflamed livers. IL-6-type cytokines are mediators of inflammation and almost all members signal via the receptor subunit gp130 and the downstream signalling molecule STAT3. We here summarize current knowledge on how gp130 signalling and STAT3 in tumour cells and cells of the tumour micro-environment drives hepatic tumorigenesis. We furthermore discuss very recent findings describing also anti-tumorigenic roles of gp130/STAT3 and important considerations for therapeutic interventions.
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spelling pubmed-84435192021-10-01 The two facets of gp130 signalling in liver tumorigenesis Schmidt-Arras, Dirk Galun, Eithan Rose-John, Stefan Semin Immunopathol Review The liver is a vital organ with multiple functions and a large regenerative capacity. Tumours of the liver are the second most frequently cause of cancer-related death and develop in chronically inflamed livers. IL-6-type cytokines are mediators of inflammation and almost all members signal via the receptor subunit gp130 and the downstream signalling molecule STAT3. We here summarize current knowledge on how gp130 signalling and STAT3 in tumour cells and cells of the tumour micro-environment drives hepatic tumorigenesis. We furthermore discuss very recent findings describing also anti-tumorigenic roles of gp130/STAT3 and important considerations for therapeutic interventions. Springer Berlin Heidelberg 2021-05-28 2021 /pmc/articles/PMC8443519/ /pubmed/34047814 http://dx.doi.org/10.1007/s00281-021-00861-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Schmidt-Arras, Dirk
Galun, Eithan
Rose-John, Stefan
The two facets of gp130 signalling in liver tumorigenesis
title The two facets of gp130 signalling in liver tumorigenesis
title_full The two facets of gp130 signalling in liver tumorigenesis
title_fullStr The two facets of gp130 signalling in liver tumorigenesis
title_full_unstemmed The two facets of gp130 signalling in liver tumorigenesis
title_short The two facets of gp130 signalling in liver tumorigenesis
title_sort two facets of gp130 signalling in liver tumorigenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443519/
https://www.ncbi.nlm.nih.gov/pubmed/34047814
http://dx.doi.org/10.1007/s00281-021-00861-0
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