Functional heterogeneity of CD4(+) T cells in liver inflammation

CD4(+) T cells play an essential role in orchestrating adequate immunity, but their overactivity has been associated with the development of immune-mediated inflammatory diseases, including liver inflammatory diseases. These cells can be subclassified according to their maturation stage, cytokine pr...

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Detalles Bibliográficos
Autores principales: Muscate, Franziska, Woestemeier, Anna, Gagliani, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443520/
https://www.ncbi.nlm.nih.gov/pubmed/34463867
http://dx.doi.org/10.1007/s00281-021-00881-w
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author Muscate, Franziska
Woestemeier, Anna
Gagliani, Nicola
author_facet Muscate, Franziska
Woestemeier, Anna
Gagliani, Nicola
author_sort Muscate, Franziska
collection PubMed
description CD4(+) T cells play an essential role in orchestrating adequate immunity, but their overactivity has been associated with the development of immune-mediated inflammatory diseases, including liver inflammatory diseases. These cells can be subclassified according to their maturation stage, cytokine profile, and pro or anti-inflammatory functions, i.e., functional heterogeneity. In this review, we summarize what has been discovered so far regarding the role of the different CD4(+) T cell polarization states in the progression of two prominent and still different liver inflammatory diseases: non-alcoholic steatohepatitis (NASH) and autoimmune hepatitis (AIH). Finally, the potential of CD4(+) T cells as a therapeutic target in both NASH and AIH is discussed.
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spelling pubmed-84435202021-10-01 Functional heterogeneity of CD4(+) T cells in liver inflammation Muscate, Franziska Woestemeier, Anna Gagliani, Nicola Semin Immunopathol Review CD4(+) T cells play an essential role in orchestrating adequate immunity, but their overactivity has been associated with the development of immune-mediated inflammatory diseases, including liver inflammatory diseases. These cells can be subclassified according to their maturation stage, cytokine profile, and pro or anti-inflammatory functions, i.e., functional heterogeneity. In this review, we summarize what has been discovered so far regarding the role of the different CD4(+) T cell polarization states in the progression of two prominent and still different liver inflammatory diseases: non-alcoholic steatohepatitis (NASH) and autoimmune hepatitis (AIH). Finally, the potential of CD4(+) T cells as a therapeutic target in both NASH and AIH is discussed. Springer Berlin Heidelberg 2021-08-31 2021 /pmc/articles/PMC8443520/ /pubmed/34463867 http://dx.doi.org/10.1007/s00281-021-00881-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Muscate, Franziska
Woestemeier, Anna
Gagliani, Nicola
Functional heterogeneity of CD4(+) T cells in liver inflammation
title Functional heterogeneity of CD4(+) T cells in liver inflammation
title_full Functional heterogeneity of CD4(+) T cells in liver inflammation
title_fullStr Functional heterogeneity of CD4(+) T cells in liver inflammation
title_full_unstemmed Functional heterogeneity of CD4(+) T cells in liver inflammation
title_short Functional heterogeneity of CD4(+) T cells in liver inflammation
title_sort functional heterogeneity of cd4(+) t cells in liver inflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443520/
https://www.ncbi.nlm.nih.gov/pubmed/34463867
http://dx.doi.org/10.1007/s00281-021-00881-w
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