Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells

The p53 isoform, Δ133p53β, is critical in promoting cancer. Here we report that Δ133p53β activity is regulated through an aggregation-dependent mechanism. Δ133p53β aggregates were observed in cancer cells and tumour biopsies. The Δ133p53β aggregation depends on association with interacting partners...

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Detalles Bibliográficos
Autores principales: Arsic, Nikola, Slatter, Tania, Gadea, Gilles, Villain, Etienne, Fournet, Aurelie, Kazantseva, Marina, Allemand, Frédéric, Sibille, Nathalie, Seveno, Martial, de Rossi, Sylvain, Mehta, Sunali, Urbach, Serge, Bourdon, Jean-Christophe, Bernado, Pau, Kajava, Andrey V., Braithwaite, Antony, Roux, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443592/
https://www.ncbi.nlm.nih.gov/pubmed/34526502
http://dx.doi.org/10.1038/s41467-021-25550-2

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