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Connectivity alterations in autism reflect functional idiosyncrasy
Autism spectrum disorder (ASD) is commonly understood as an alteration of brain networks, yet case-control analyses against typically-developing controls (TD) have yielded inconsistent results. Here, we devised a novel approach to profile the inter-individual variability in functional network organi...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443598/ https://www.ncbi.nlm.nih.gov/pubmed/34526654 http://dx.doi.org/10.1038/s42003-021-02572-6 |
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author | Benkarim, Oualid Paquola, Casey Park, Bo-yong Hong, Seok-Jun Royer, Jessica Vos de Wael, Reinder Lariviere, Sara Valk, Sofie Bzdok, Danilo Mottron, Laurent C. Bernhardt, Boris |
author_facet | Benkarim, Oualid Paquola, Casey Park, Bo-yong Hong, Seok-Jun Royer, Jessica Vos de Wael, Reinder Lariviere, Sara Valk, Sofie Bzdok, Danilo Mottron, Laurent C. Bernhardt, Boris |
author_sort | Benkarim, Oualid |
collection | PubMed |
description | Autism spectrum disorder (ASD) is commonly understood as an alteration of brain networks, yet case-control analyses against typically-developing controls (TD) have yielded inconsistent results. Here, we devised a novel approach to profile the inter-individual variability in functional network organization and tested whether such idiosyncrasy contributes to connectivity alterations in ASD. Studying a multi-centric dataset with 157 ASD and 172 TD, we obtained robust evidence for increased idiosyncrasy in ASD relative to TD in default mode, somatomotor and attention networks, but also reduced idiosyncrasy in lateral temporal cortices. Idiosyncrasy increased with age and significantly correlated with symptom severity in ASD. Furthermore, while patterns of functional idiosyncrasy were not correlated with ASD-related cortical thickness alterations, they co-localized with the expression patterns of ASD risk genes. Notably, we could demonstrate that patterns of atypical idiosyncrasy in ASD closely overlapped with connectivity alterations that are measurable with conventional case-control designs and may, thus, be a principal driver of inconsistency in the autism connectomics literature. These findings support important interactions between inter-individual heterogeneity in autism and functional signatures. Our findings provide novel biomarkers to study atypical brain development and may consolidate prior research findings on the variable nature of connectome level anomalies in autism. |
format | Online Article Text |
id | pubmed-8443598 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-84435982021-10-22 Connectivity alterations in autism reflect functional idiosyncrasy Benkarim, Oualid Paquola, Casey Park, Bo-yong Hong, Seok-Jun Royer, Jessica Vos de Wael, Reinder Lariviere, Sara Valk, Sofie Bzdok, Danilo Mottron, Laurent C. Bernhardt, Boris Commun Biol Article Autism spectrum disorder (ASD) is commonly understood as an alteration of brain networks, yet case-control analyses against typically-developing controls (TD) have yielded inconsistent results. Here, we devised a novel approach to profile the inter-individual variability in functional network organization and tested whether such idiosyncrasy contributes to connectivity alterations in ASD. Studying a multi-centric dataset with 157 ASD and 172 TD, we obtained robust evidence for increased idiosyncrasy in ASD relative to TD in default mode, somatomotor and attention networks, but also reduced idiosyncrasy in lateral temporal cortices. Idiosyncrasy increased with age and significantly correlated with symptom severity in ASD. Furthermore, while patterns of functional idiosyncrasy were not correlated with ASD-related cortical thickness alterations, they co-localized with the expression patterns of ASD risk genes. Notably, we could demonstrate that patterns of atypical idiosyncrasy in ASD closely overlapped with connectivity alterations that are measurable with conventional case-control designs and may, thus, be a principal driver of inconsistency in the autism connectomics literature. These findings support important interactions between inter-individual heterogeneity in autism and functional signatures. Our findings provide novel biomarkers to study atypical brain development and may consolidate prior research findings on the variable nature of connectome level anomalies in autism. Nature Publishing Group UK 2021-09-15 /pmc/articles/PMC8443598/ /pubmed/34526654 http://dx.doi.org/10.1038/s42003-021-02572-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Benkarim, Oualid Paquola, Casey Park, Bo-yong Hong, Seok-Jun Royer, Jessica Vos de Wael, Reinder Lariviere, Sara Valk, Sofie Bzdok, Danilo Mottron, Laurent C. Bernhardt, Boris Connectivity alterations in autism reflect functional idiosyncrasy |
title | Connectivity alterations in autism reflect functional idiosyncrasy |
title_full | Connectivity alterations in autism reflect functional idiosyncrasy |
title_fullStr | Connectivity alterations in autism reflect functional idiosyncrasy |
title_full_unstemmed | Connectivity alterations in autism reflect functional idiosyncrasy |
title_short | Connectivity alterations in autism reflect functional idiosyncrasy |
title_sort | connectivity alterations in autism reflect functional idiosyncrasy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443598/ https://www.ncbi.nlm.nih.gov/pubmed/34526654 http://dx.doi.org/10.1038/s42003-021-02572-6 |
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