CRISPR/Cas9 small promoter deletion in H19 lncRNA is associated with altered cell morphology and proliferation

The imprinted H19 long non-coding RNA, a knowing oncofetal gene, presents a controversial role during the carcinogenesis process since its tumor suppressor or oncogenic activity is not completely elucidated. Since H19 lncRNA is involved in many biological pathways related to tumorigenesis, we sought...

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Detalles Bibliográficos
Autores principales: da Silva Santos, Renan, Pinheiro, Daniel Pascoalino, Teixeira, Louhanna Pinheiro Rodrigues, Sales, Sarah Leyenne Alves, dos Santos Luciano, Maria Claudia, de Lima Melo, Mayara Magna, Pinheiro, Ronald Feitosa, Tavares, Kaio César Simiano, Furtado, Gilvan Pessoa, Pessoa, Claudia, Furtado, Cristiana Libardi Miranda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443613/
https://www.ncbi.nlm.nih.gov/pubmed/34526543
http://dx.doi.org/10.1038/s41598-021-97058-0

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