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Semiautomated 3D mapping of aneurysmal wall enhancement with 7T-MRI

Aneurysm wall enhancement (AWE) after the administration of contrast gadolinium is a potential biomarker of unstable intracranial aneurysms. While most studies determine AWE subjectively, this study comprehensively quantified AWE in 3D imaging using a semi-automated method. Thirty patients with 33 u...

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Autores principales: Raghuram, Ashrita, Varon, Alberto, Roa, Jorge A., Ishii, Daizo, Lu, Yongjun, Raghavan, Madhavan L., Wu, Chaorong, Magnotta, Vincent A., Hasan, David M., Koscik, Timothy R., Samaniego, Edgar A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443635/
https://www.ncbi.nlm.nih.gov/pubmed/34526579
http://dx.doi.org/10.1038/s41598-021-97727-0
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author Raghuram, Ashrita
Varon, Alberto
Roa, Jorge A.
Ishii, Daizo
Lu, Yongjun
Raghavan, Madhavan L.
Wu, Chaorong
Magnotta, Vincent A.
Hasan, David M.
Koscik, Timothy R.
Samaniego, Edgar A.
author_facet Raghuram, Ashrita
Varon, Alberto
Roa, Jorge A.
Ishii, Daizo
Lu, Yongjun
Raghavan, Madhavan L.
Wu, Chaorong
Magnotta, Vincent A.
Hasan, David M.
Koscik, Timothy R.
Samaniego, Edgar A.
author_sort Raghuram, Ashrita
collection PubMed
description Aneurysm wall enhancement (AWE) after the administration of contrast gadolinium is a potential biomarker of unstable intracranial aneurysms. While most studies determine AWE subjectively, this study comprehensively quantified AWE in 3D imaging using a semi-automated method. Thirty patients with 33 unruptured intracranial aneurysms prospectively underwent high-resolution imaging with 7T-MRI. The signal intensity (SI) of the aneurysm wall was mapped and normalized to the pituitary stalk (PS) and corpus callosum (CC). The CC proved to be a more reliable normalizing structure in detecting contrast enhancement (p < 0.0001). 3D-heatmaps and histogram analysis of AWE were used to generate the following metrics: specific aneurysm wall enhancement (SAWE), general aneurysm wall enhancement (GAWE) and focal aneurysm wall enhancement (FAWE). GAWE was more accurate in detecting known morphological determinants of aneurysm instability such as size ≥ 7 mm (p = 0.049), size ratio (p = 0.01) and aspect ratio (p = 0.002). SAWE and FAWE were aneurysm specific metrics used to characterize enhancement patterns within the aneurysm wall and the distribution of enhancement along the aneurysm. Blebs were easily identified on 3D-heatmaps and were more enhancing than aneurysm sacs (p = 0.0017). 3D-AWE mapping may be a powerful objective tool in characterizing different biological processes of the aneurysm wall.
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spelling pubmed-84436352021-09-20 Semiautomated 3D mapping of aneurysmal wall enhancement with 7T-MRI Raghuram, Ashrita Varon, Alberto Roa, Jorge A. Ishii, Daizo Lu, Yongjun Raghavan, Madhavan L. Wu, Chaorong Magnotta, Vincent A. Hasan, David M. Koscik, Timothy R. Samaniego, Edgar A. Sci Rep Article Aneurysm wall enhancement (AWE) after the administration of contrast gadolinium is a potential biomarker of unstable intracranial aneurysms. While most studies determine AWE subjectively, this study comprehensively quantified AWE in 3D imaging using a semi-automated method. Thirty patients with 33 unruptured intracranial aneurysms prospectively underwent high-resolution imaging with 7T-MRI. The signal intensity (SI) of the aneurysm wall was mapped and normalized to the pituitary stalk (PS) and corpus callosum (CC). The CC proved to be a more reliable normalizing structure in detecting contrast enhancement (p < 0.0001). 3D-heatmaps and histogram analysis of AWE were used to generate the following metrics: specific aneurysm wall enhancement (SAWE), general aneurysm wall enhancement (GAWE) and focal aneurysm wall enhancement (FAWE). GAWE was more accurate in detecting known morphological determinants of aneurysm instability such as size ≥ 7 mm (p = 0.049), size ratio (p = 0.01) and aspect ratio (p = 0.002). SAWE and FAWE were aneurysm specific metrics used to characterize enhancement patterns within the aneurysm wall and the distribution of enhancement along the aneurysm. Blebs were easily identified on 3D-heatmaps and were more enhancing than aneurysm sacs (p = 0.0017). 3D-AWE mapping may be a powerful objective tool in characterizing different biological processes of the aneurysm wall. Nature Publishing Group UK 2021-09-15 /pmc/articles/PMC8443635/ /pubmed/34526579 http://dx.doi.org/10.1038/s41598-021-97727-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Raghuram, Ashrita
Varon, Alberto
Roa, Jorge A.
Ishii, Daizo
Lu, Yongjun
Raghavan, Madhavan L.
Wu, Chaorong
Magnotta, Vincent A.
Hasan, David M.
Koscik, Timothy R.
Samaniego, Edgar A.
Semiautomated 3D mapping of aneurysmal wall enhancement with 7T-MRI
title Semiautomated 3D mapping of aneurysmal wall enhancement with 7T-MRI
title_full Semiautomated 3D mapping of aneurysmal wall enhancement with 7T-MRI
title_fullStr Semiautomated 3D mapping of aneurysmal wall enhancement with 7T-MRI
title_full_unstemmed Semiautomated 3D mapping of aneurysmal wall enhancement with 7T-MRI
title_short Semiautomated 3D mapping of aneurysmal wall enhancement with 7T-MRI
title_sort semiautomated 3d mapping of aneurysmal wall enhancement with 7t-mri
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443635/
https://www.ncbi.nlm.nih.gov/pubmed/34526579
http://dx.doi.org/10.1038/s41598-021-97727-0
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