Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling

E3-ubiquitin ligase Cullin3 (Cul3) is a high confidence risk gene for autism spectrum disorder (ASD) and developmental delay (DD). To investigate how Cul3 mutations impact brain development, we generated a haploinsufficient Cul3 mouse model using CRISPR/Cas9 genome engineering. Cul3 mutant mice exhi...

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Detalles Bibliográficos
Autores principales: Amar, Megha, Pramod, Akula Bala, Yu, Nam-Kyung, Herrera, Victor Munive, Qiu, Lily R., Moran-Losada, Patricia, Zhang, Pan, Trujillo, Cleber A., Ellegood, Jacob, Urresti, Jorge, Chau, Kevin, Diedrich, Jolene, Chen, Jiaye, Gutierrez, Jessica, Sebat, Jonathan, Ramanathan, Dhakshin, Lerch, Jason P., Yates, John R., Muotri, Alysson R., Iakoucheva, Lilia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443683/
https://www.ncbi.nlm.nih.gov/pubmed/33727673
http://dx.doi.org/10.1038/s41380-021-01052-x

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