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Purkinje cells located in the adult zebrafish valvula cerebelli exhibit variable functional responses
Purkinje cells are critically involved in processing the cerebellar functions by shaping and coordinating commands that they receive. Here, we demonstrate experimentally that in the adult zebrafish valvular part of the cerebellum, the Purkinje cells exhibited variable firing and functional responses...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443705/ https://www.ncbi.nlm.nih.gov/pubmed/34526620 http://dx.doi.org/10.1038/s41598-021-98035-3 |
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author | Chang, Weipang Pedroni, Andrea Köster, Reinhard W. Giacomello, Stefania Ampatzis, Konstantinos |
author_facet | Chang, Weipang Pedroni, Andrea Köster, Reinhard W. Giacomello, Stefania Ampatzis, Konstantinos |
author_sort | Chang, Weipang |
collection | PubMed |
description | Purkinje cells are critically involved in processing the cerebellar functions by shaping and coordinating commands that they receive. Here, we demonstrate experimentally that in the adult zebrafish valvular part of the cerebellum, the Purkinje cells exhibited variable firing and functional responses and allowed the categorization into three firing classes. Compared with the Purkinje cells in the corpus cerebelli, the valvular Purkinje cells receive weak and occasional input from the inferior olive and are not active during locomotion. Together, our findings expand further the regional functional differences of the Purkinje cell population and expose their non-locomotor functionality. |
format | Online Article Text |
id | pubmed-8443705 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-84437052021-09-20 Purkinje cells located in the adult zebrafish valvula cerebelli exhibit variable functional responses Chang, Weipang Pedroni, Andrea Köster, Reinhard W. Giacomello, Stefania Ampatzis, Konstantinos Sci Rep Article Purkinje cells are critically involved in processing the cerebellar functions by shaping and coordinating commands that they receive. Here, we demonstrate experimentally that in the adult zebrafish valvular part of the cerebellum, the Purkinje cells exhibited variable firing and functional responses and allowed the categorization into three firing classes. Compared with the Purkinje cells in the corpus cerebelli, the valvular Purkinje cells receive weak and occasional input from the inferior olive and are not active during locomotion. Together, our findings expand further the regional functional differences of the Purkinje cell population and expose their non-locomotor functionality. Nature Publishing Group UK 2021-09-15 /pmc/articles/PMC8443705/ /pubmed/34526620 http://dx.doi.org/10.1038/s41598-021-98035-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Chang, Weipang Pedroni, Andrea Köster, Reinhard W. Giacomello, Stefania Ampatzis, Konstantinos Purkinje cells located in the adult zebrafish valvula cerebelli exhibit variable functional responses |
title | Purkinje cells located in the adult zebrafish valvula cerebelli exhibit variable functional responses |
title_full | Purkinje cells located in the adult zebrafish valvula cerebelli exhibit variable functional responses |
title_fullStr | Purkinje cells located in the adult zebrafish valvula cerebelli exhibit variable functional responses |
title_full_unstemmed | Purkinje cells located in the adult zebrafish valvula cerebelli exhibit variable functional responses |
title_short | Purkinje cells located in the adult zebrafish valvula cerebelli exhibit variable functional responses |
title_sort | purkinje cells located in the adult zebrafish valvula cerebelli exhibit variable functional responses |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443705/ https://www.ncbi.nlm.nih.gov/pubmed/34526620 http://dx.doi.org/10.1038/s41598-021-98035-3 |
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