Chlamydia evasion of neutrophil host defense results in NLRP3 dependent myeloid-mediated sterile inflammation through the purinergic P2X7 receptor

Chlamydia trachomatis infection causes severe inflammatory disease resulting in blindness and infertility. The pathophysiology of these diseases remains elusive but myeloid cell-associated inflammation has been implicated. Here we show NLRP3 inflammasome activation is essential for driving a macroph...

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Detalles Bibliográficos
Autores principales: Yang, Chunfu, Lei, Lei, Collins, John W. Marshall, Briones, Michael, Ma, Li, Sturdevant, Gail L., Su, Hua, Kashyap, Anuj K., Dorward, David, Bock, Kevin W., Moore, Ian N., Bonner, Christine, Chen, Chih-Yu, Martens, Craig A., Ricklefs, Stacy, Yamamoto, Masahiro, Takeda, Kiyoshi, Iwakura, Yoichiro, McClarty, Grant, Caldwell, Harlan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443728/
https://www.ncbi.nlm.nih.gov/pubmed/34526512
http://dx.doi.org/10.1038/s41467-021-25749-3

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