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Biomolecular simulation based machine learning models accurately predict sites of tolerability to the unnatural amino acid acridonylalanine

The incorporation of unnatural amino acids (Uaas) has provided an avenue for novel chemistries to be explored in biological systems. However, the successful application of Uaas is often hampered by site-specific impacts on protein yield and solubility. Although previous efforts to identify features...

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Detalles Bibliográficos
Autores principales:	Giannakoulias, Sam, Shringari, Sumant R., Ferrie, John J., Petersson, E. James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443755/ https://www.ncbi.nlm.nih.gov/pubmed/34526629 http://dx.doi.org/10.1038/s41598-021-97965-2

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