The Pathological Mechanism and Potential Application of IL-38 in Autoimmune Diseases

Interleukin-38 (IL-38), a new cytokine of interleukin-1 family (IL-1F), is expressed in the human heart, kidney, skin, etc. Recently, new evidence indicated that IL-38 is involved in the process of different autoimmune diseases. Autoimmune diseases are a cluster of diseases accompanied with tissue d...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Miao-miao, Yuan, Xin-rong, Shi, Xiang, Zhu, Xing-Yu, Su, Yue, Xiong, De-Kai, Zhang, Xing-Min, Zhou, Huan, Wang, Ji-Nian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443783/
https://www.ncbi.nlm.nih.gov/pubmed/34539413
http://dx.doi.org/10.3389/fphar.2021.732790
_version_ 1784568360818704384
author Han, Miao-miao
Yuan, Xin-rong
Shi, Xiang
Zhu, Xing-Yu
Su, Yue
Xiong, De-Kai
Zhang, Xing-Min
Zhou, Huan
Wang, Ji-Nian
author_facet Han, Miao-miao
Yuan, Xin-rong
Shi, Xiang
Zhu, Xing-Yu
Su, Yue
Xiong, De-Kai
Zhang, Xing-Min
Zhou, Huan
Wang, Ji-Nian
author_sort Han, Miao-miao
collection PubMed
description Interleukin-38 (IL-38), a new cytokine of interleukin-1 family (IL-1F), is expressed in the human heart, kidney, skin, etc. Recently, new evidence indicated that IL-38 is involved in the process of different autoimmune diseases. Autoimmune diseases are a cluster of diseases accompanied with tissue damage caused by autoimmune reactions, including rheumatoid arthritis (RA), psoriasis, etc. This review summarized the links between IL-38 and autoimmune diseases, as well as the latest knowledge about the function and regulatory mechanism of IL-38 in autoimmune diseases. Especially, this review focused on the differentiation of immune cells and explore future prospects, such as the application of IL-38 in new technologies. Understanding the function of IL-38 is helpful to shed light on the progress of autoimmune diseases.
format Online
Article
Text
id pubmed-8443783
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-84437832021-09-17 The Pathological Mechanism and Potential Application of IL-38 in Autoimmune Diseases Han, Miao-miao Yuan, Xin-rong Shi, Xiang Zhu, Xing-Yu Su, Yue Xiong, De-Kai Zhang, Xing-Min Zhou, Huan Wang, Ji-Nian Front Pharmacol Pharmacology Interleukin-38 (IL-38), a new cytokine of interleukin-1 family (IL-1F), is expressed in the human heart, kidney, skin, etc. Recently, new evidence indicated that IL-38 is involved in the process of different autoimmune diseases. Autoimmune diseases are a cluster of diseases accompanied with tissue damage caused by autoimmune reactions, including rheumatoid arthritis (RA), psoriasis, etc. This review summarized the links between IL-38 and autoimmune diseases, as well as the latest knowledge about the function and regulatory mechanism of IL-38 in autoimmune diseases. Especially, this review focused on the differentiation of immune cells and explore future prospects, such as the application of IL-38 in new technologies. Understanding the function of IL-38 is helpful to shed light on the progress of autoimmune diseases. Frontiers Media S.A. 2021-09-02 /pmc/articles/PMC8443783/ /pubmed/34539413 http://dx.doi.org/10.3389/fphar.2021.732790 Text en Copyright © 2021 Han, Yuan, Shi, Zhu, Su, Xiong, Zhang, Zhou and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Han, Miao-miao
Yuan, Xin-rong
Shi, Xiang
Zhu, Xing-Yu
Su, Yue
Xiong, De-Kai
Zhang, Xing-Min
Zhou, Huan
Wang, Ji-Nian
The Pathological Mechanism and Potential Application of IL-38 in Autoimmune Diseases
title The Pathological Mechanism and Potential Application of IL-38 in Autoimmune Diseases
title_full The Pathological Mechanism and Potential Application of IL-38 in Autoimmune Diseases
title_fullStr The Pathological Mechanism and Potential Application of IL-38 in Autoimmune Diseases
title_full_unstemmed The Pathological Mechanism and Potential Application of IL-38 in Autoimmune Diseases
title_short The Pathological Mechanism and Potential Application of IL-38 in Autoimmune Diseases
title_sort pathological mechanism and potential application of il-38 in autoimmune diseases
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443783/
https://www.ncbi.nlm.nih.gov/pubmed/34539413
http://dx.doi.org/10.3389/fphar.2021.732790
work_keys_str_mv AT hanmiaomiao thepathologicalmechanismandpotentialapplicationofil38inautoimmunediseases
AT yuanxinrong thepathologicalmechanismandpotentialapplicationofil38inautoimmunediseases
AT shixiang thepathologicalmechanismandpotentialapplicationofil38inautoimmunediseases
AT zhuxingyu thepathologicalmechanismandpotentialapplicationofil38inautoimmunediseases
AT suyue thepathologicalmechanismandpotentialapplicationofil38inautoimmunediseases
AT xiongdekai thepathologicalmechanismandpotentialapplicationofil38inautoimmunediseases
AT zhangxingmin thepathologicalmechanismandpotentialapplicationofil38inautoimmunediseases
AT zhouhuan thepathologicalmechanismandpotentialapplicationofil38inautoimmunediseases
AT wangjinian thepathologicalmechanismandpotentialapplicationofil38inautoimmunediseases
AT hanmiaomiao pathologicalmechanismandpotentialapplicationofil38inautoimmunediseases
AT yuanxinrong pathologicalmechanismandpotentialapplicationofil38inautoimmunediseases
AT shixiang pathologicalmechanismandpotentialapplicationofil38inautoimmunediseases
AT zhuxingyu pathologicalmechanismandpotentialapplicationofil38inautoimmunediseases
AT suyue pathologicalmechanismandpotentialapplicationofil38inautoimmunediseases
AT xiongdekai pathologicalmechanismandpotentialapplicationofil38inautoimmunediseases
AT zhangxingmin pathologicalmechanismandpotentialapplicationofil38inautoimmunediseases
AT zhouhuan pathologicalmechanismandpotentialapplicationofil38inautoimmunediseases
AT wangjinian pathologicalmechanismandpotentialapplicationofil38inautoimmunediseases

Ejemplares similares