First fluconazole-resistant Candida auris isolated from fungal otitis in Iran

BACKGROUND AND PURPOSE: Candida auris, as a new characterized pathogenic yeast, has attracted remarkable attention in the recent decade due to its rapid global emergence and multidrug resistance traits. This unique species is able to cause nosocomial outbreaks and tolerate adverse conditions; howeve...

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Autores principales: Taghizadeh Armaki, Mojtaba, Mahdavi Omran, Saeid, Kiakojuri, Keyvan, Khojasteh, Shaghayegh, Jafarzadeh, Jalal, Tavakoli, Mahin, Badali, Hamid, Haghani, Iman, Shokohi, Tahereh, Taghi Hedayati, Mohammad, Abastabar, Mahdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Society of Medical Mycology 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443880/
https://www.ncbi.nlm.nih.gov/pubmed/34553098
http://dx.doi.org/10.18502/cmm.7.1.6243
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author Taghizadeh Armaki, Mojtaba
Mahdavi Omran, Saeid
Kiakojuri, Keyvan
Khojasteh, Shaghayegh
Jafarzadeh, Jalal
Tavakoli, Mahin
Badali, Hamid
Haghani, Iman
Shokohi, Tahereh
Taghi Hedayati, Mohammad
Abastabar, Mahdi
author_facet Taghizadeh Armaki, Mojtaba
Mahdavi Omran, Saeid
Kiakojuri, Keyvan
Khojasteh, Shaghayegh
Jafarzadeh, Jalal
Tavakoli, Mahin
Badali, Hamid
Haghani, Iman
Shokohi, Tahereh
Taghi Hedayati, Mohammad
Abastabar, Mahdi
author_sort Taghizadeh Armaki, Mojtaba
collection PubMed
description BACKGROUND AND PURPOSE: Candida auris, as a new characterized pathogenic yeast, has attracted remarkable attention in the recent decade due to its rapid global emergence and multidrug resistance traits. This unique species is able to cause nosocomial outbreaks and tolerate adverse conditions; however, it has been mostly misidentified by conventional methods. CASE REPORT: This report aimed to describe the first fluconazole-resistant case of C. auris otitis in an immunocompetent patient in Iran. The isolate showed minimum inhibitory concentration of ≥ 32 μg/ml for fluconazole; however, the patient was treated with topical clotrimazole and miconazole with no recurrence. CONCLUSION: This was the second strain of C. auris isolated from otitis in Iran which was fluconazole-resistant, unlike the first Iranian isolate.
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spelling pubmed-84438802021-09-21 First fluconazole-resistant Candida auris isolated from fungal otitis in Iran Taghizadeh Armaki, Mojtaba Mahdavi Omran, Saeid Kiakojuri, Keyvan Khojasteh, Shaghayegh Jafarzadeh, Jalal Tavakoli, Mahin Badali, Hamid Haghani, Iman Shokohi, Tahereh Taghi Hedayati, Mohammad Abastabar, Mahdi Curr Med Mycol Case Report BACKGROUND AND PURPOSE: Candida auris, as a new characterized pathogenic yeast, has attracted remarkable attention in the recent decade due to its rapid global emergence and multidrug resistance traits. This unique species is able to cause nosocomial outbreaks and tolerate adverse conditions; however, it has been mostly misidentified by conventional methods. CASE REPORT: This report aimed to describe the first fluconazole-resistant case of C. auris otitis in an immunocompetent patient in Iran. The isolate showed minimum inhibitory concentration of ≥ 32 μg/ml for fluconazole; however, the patient was treated with topical clotrimazole and miconazole with no recurrence. CONCLUSION: This was the second strain of C. auris isolated from otitis in Iran which was fluconazole-resistant, unlike the first Iranian isolate. Iranian Society of Medical Mycology 2021-03 /pmc/articles/PMC8443880/ /pubmed/34553098 http://dx.doi.org/10.18502/cmm.7.1.6243 Text en Copyright: © 2021, Published by Mazandaran University of Medical Sciences on behalf of Iranian Society of Medical Mycology and Invasive Fungi Research Center. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 Unported License, ( http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Taghizadeh Armaki, Mojtaba
Mahdavi Omran, Saeid
Kiakojuri, Keyvan
Khojasteh, Shaghayegh
Jafarzadeh, Jalal
Tavakoli, Mahin
Badali, Hamid
Haghani, Iman
Shokohi, Tahereh
Taghi Hedayati, Mohammad
Abastabar, Mahdi
First fluconazole-resistant Candida auris isolated from fungal otitis in Iran
title First fluconazole-resistant Candida auris isolated from fungal otitis in Iran
title_full First fluconazole-resistant Candida auris isolated from fungal otitis in Iran
title_fullStr First fluconazole-resistant Candida auris isolated from fungal otitis in Iran
title_full_unstemmed First fluconazole-resistant Candida auris isolated from fungal otitis in Iran
title_short First fluconazole-resistant Candida auris isolated from fungal otitis in Iran
title_sort first fluconazole-resistant candida auris isolated from fungal otitis in iran
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443880/
https://www.ncbi.nlm.nih.gov/pubmed/34553098
http://dx.doi.org/10.18502/cmm.7.1.6243
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