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Exploring the Pleiotropic Genes and Therapeutic Targets Associated with Heart Failure and Chronic Kidney Disease by Integrating metaCCA and SGLT2 Inhibitors' Target Prediction

BACKGROUND: Previous studies have shown that heart failure (HF) and chronic kidney disease (CKD) have common genetic mechanisms, overlapping pathophysiological pathways, and therapeutic drug—sodium-glucose cotransporter 2 (SGLT2) inhibitors. METHODS: The genetic pleiotropy metaCCA method was applied...

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Detalles Bibliográficos
Autores principales:	Li, Huanqiang, Mai, Ziling, Yu, Sijia, Wang, Bo, Lai, Wenguang, Chen, Guanzhong, Zhou, Chunyun, Liu, Jin, Yang, Yongquan, Chen, Shiqun, Liu, Yong, Chen, Jiyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443964/ https://www.ncbi.nlm.nih.gov/pubmed/34540994 http://dx.doi.org/10.1155/2021/4229194

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