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First description of immune complex vasculitis after COVID-19 vaccination with BNT162b2: a case report
BACKGROUND: Cases of immune complex vasculitis have been reported following COVID-19 infections; so far none in association with novel mRNA-based COVID-19 vaccination. This case report describes a cutaneous immune complex vasculitis after vaccination with BNT162b2. CASE PRESENTATION: A 76-year old m...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443965/ https://www.ncbi.nlm.nih.gov/pubmed/34530771 http://dx.doi.org/10.1186/s12879-021-06655-x |
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author | Mücke, Victoria Therese Knop, Viola Mücke, Marcus Maximilian Ochsendorf, Falk Zeuzem, Stefan |
author_facet | Mücke, Victoria Therese Knop, Viola Mücke, Marcus Maximilian Ochsendorf, Falk Zeuzem, Stefan |
author_sort | Mücke, Victoria Therese |
collection | PubMed |
description | BACKGROUND: Cases of immune complex vasculitis have been reported following COVID-19 infections; so far none in association with novel mRNA-based COVID-19 vaccination. This case report describes a cutaneous immune complex vasculitis after vaccination with BNT162b2. CASE PRESENTATION: A 76-year old male with liver cirrhosis developed an immune complex vasculitis 12 days after the second injection of BNT162b2. On physical examination, the patient presented with pruritic purpuric macules on hands and feet, flexor and extensor parts of both legs and thighs and lower abdomen, and bloody diarrhoea. Laboratory testing showed elevated inflammatory markers. After short treatment with oral steroids all clinical manifestations and laboratory findings resolved. CONCLUSIONS: An increasing number of clinical manifestations have been attributed to COVID-19 infection and vaccination. This is the first written report of immune complex vasculitis after vaccination with BNT162b2. We present our case report and a discussion in the light of type three hypersensitivity reaction. |
format | Online Article Text |
id | pubmed-8443965 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-84439652021-09-16 First description of immune complex vasculitis after COVID-19 vaccination with BNT162b2: a case report Mücke, Victoria Therese Knop, Viola Mücke, Marcus Maximilian Ochsendorf, Falk Zeuzem, Stefan BMC Infect Dis Case Report BACKGROUND: Cases of immune complex vasculitis have been reported following COVID-19 infections; so far none in association with novel mRNA-based COVID-19 vaccination. This case report describes a cutaneous immune complex vasculitis after vaccination with BNT162b2. CASE PRESENTATION: A 76-year old male with liver cirrhosis developed an immune complex vasculitis 12 days after the second injection of BNT162b2. On physical examination, the patient presented with pruritic purpuric macules on hands and feet, flexor and extensor parts of both legs and thighs and lower abdomen, and bloody diarrhoea. Laboratory testing showed elevated inflammatory markers. After short treatment with oral steroids all clinical manifestations and laboratory findings resolved. CONCLUSIONS: An increasing number of clinical manifestations have been attributed to COVID-19 infection and vaccination. This is the first written report of immune complex vasculitis after vaccination with BNT162b2. We present our case report and a discussion in the light of type three hypersensitivity reaction. BioMed Central 2021-09-16 /pmc/articles/PMC8443965/ /pubmed/34530771 http://dx.doi.org/10.1186/s12879-021-06655-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Mücke, Victoria Therese Knop, Viola Mücke, Marcus Maximilian Ochsendorf, Falk Zeuzem, Stefan First description of immune complex vasculitis after COVID-19 vaccination with BNT162b2: a case report |
title | First description of immune complex vasculitis after COVID-19 vaccination with BNT162b2: a case report |
title_full | First description of immune complex vasculitis after COVID-19 vaccination with BNT162b2: a case report |
title_fullStr | First description of immune complex vasculitis after COVID-19 vaccination with BNT162b2: a case report |
title_full_unstemmed | First description of immune complex vasculitis after COVID-19 vaccination with BNT162b2: a case report |
title_short | First description of immune complex vasculitis after COVID-19 vaccination with BNT162b2: a case report |
title_sort | first description of immune complex vasculitis after covid-19 vaccination with bnt162b2: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443965/ https://www.ncbi.nlm.nih.gov/pubmed/34530771 http://dx.doi.org/10.1186/s12879-021-06655-x |
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