Cargando…

Cohort profile: a migratory cohort study of US Marines who train in Australia

PURPOSE: In 2012, US Marines and Sailors began annual deployments to Australia to participate in joint training exercises with the Australian Defence Force and other partners in the region. During their training, US service members are exposed to a variety of infectious disease threats not normally...

Descripción completa

Detalles Bibliográficos
Autores principales: Chan-Cuzydlo, Alyssa, Harrison, Dustin J, Pike, Brian L, Currie, Bart J, Mayo, Mark, Salvador, Mark G, Hulsey, William R, Azzarello, Joseph, Ellis, Jeffrey, Kim, Daniel, King-Lewis, William, Smith, Jessica Nicole, Rodriguez, Barbara, Maves, Ryan C, Lawler, James V, Schully, Kevin L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444257/
https://www.ncbi.nlm.nih.gov/pubmed/34526342
http://dx.doi.org/10.1136/bmjopen-2021-050330
_version_ 1784568452399235072
author Chan-Cuzydlo, Alyssa
Harrison, Dustin J
Pike, Brian L
Currie, Bart J
Mayo, Mark
Salvador, Mark G
Hulsey, William R
Azzarello, Joseph
Ellis, Jeffrey
Kim, Daniel
King-Lewis, William
Smith, Jessica Nicole
Rodriguez, Barbara
Maves, Ryan C
Lawler, James V
Schully, Kevin L
author_facet Chan-Cuzydlo, Alyssa
Harrison, Dustin J
Pike, Brian L
Currie, Bart J
Mayo, Mark
Salvador, Mark G
Hulsey, William R
Azzarello, Joseph
Ellis, Jeffrey
Kim, Daniel
King-Lewis, William
Smith, Jessica Nicole
Rodriguez, Barbara
Maves, Ryan C
Lawler, James V
Schully, Kevin L
author_sort Chan-Cuzydlo, Alyssa
collection PubMed
description PURPOSE: In 2012, US Marines and Sailors began annual deployments to Australia to participate in joint training exercises with the Australian Defence Force and other partners in the region. During their training, US service members are exposed to a variety of infectious disease threats not normally encountered by American citizens. This paper describes a cohort of US Marines and Sailors enrolled during five rotations to Australia between 2016 and 2020. PARTICIPANTS: Study participation is strictly voluntary. Group informational sessions are held prior to deployment to describe the study structure and goals, as well as the infectious disease threats that participants may encounter while in Australia. All participants provided written informed consent. Consented participants complete a pre-deployment questionnaire to collect data including basic demographic information, military occupational specialty, travel history, family history, basic health status and personal habits such as alcohol consumption. Blood is collected for serum, plasma and peripheral blood mononuclear cells (PBMC) processing. Data and specimen collection is repeated up to three times: before, during and after deployment. FINDINGS TO DATE: From the five rotations that comprised the 2016–2020 Marine Rotational Force-Darwin, we enrolled 1289 volunteers. Enrolments during this period were overwhelmingly white male under the age of 24 years. Most of the enrollees were junior enlisted and non-commissioned officers, with a smaller number of staff non-commissioned officers and commissioned officers, and minimal warrant officers. Over half of the enrollees had occupational specialty designations for infantry. FUTURE PLANS: In the future, we will screen samples for serological evidence of infection with Burkholderia pseudomallei, Coxiella burnetii, Ross River virus, SARS-CoV-2 and other operationally relevant pathogens endemic in Australia. Antigenic stimulation assays will be performed on PBMCs collected from seropositive individuals to characterise the immune response to these infections in this healthy American population.
format Online
Article
Text
id pubmed-8444257
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-84442572021-10-01 Cohort profile: a migratory cohort study of US Marines who train in Australia Chan-Cuzydlo, Alyssa Harrison, Dustin J Pike, Brian L Currie, Bart J Mayo, Mark Salvador, Mark G Hulsey, William R Azzarello, Joseph Ellis, Jeffrey Kim, Daniel King-Lewis, William Smith, Jessica Nicole Rodriguez, Barbara Maves, Ryan C Lawler, James V Schully, Kevin L BMJ Open Infectious Diseases PURPOSE: In 2012, US Marines and Sailors began annual deployments to Australia to participate in joint training exercises with the Australian Defence Force and other partners in the region. During their training, US service members are exposed to a variety of infectious disease threats not normally encountered by American citizens. This paper describes a cohort of US Marines and Sailors enrolled during five rotations to Australia between 2016 and 2020. PARTICIPANTS: Study participation is strictly voluntary. Group informational sessions are held prior to deployment to describe the study structure and goals, as well as the infectious disease threats that participants may encounter while in Australia. All participants provided written informed consent. Consented participants complete a pre-deployment questionnaire to collect data including basic demographic information, military occupational specialty, travel history, family history, basic health status and personal habits such as alcohol consumption. Blood is collected for serum, plasma and peripheral blood mononuclear cells (PBMC) processing. Data and specimen collection is repeated up to three times: before, during and after deployment. FINDINGS TO DATE: From the five rotations that comprised the 2016–2020 Marine Rotational Force-Darwin, we enrolled 1289 volunteers. Enrolments during this period were overwhelmingly white male under the age of 24 years. Most of the enrollees were junior enlisted and non-commissioned officers, with a smaller number of staff non-commissioned officers and commissioned officers, and minimal warrant officers. Over half of the enrollees had occupational specialty designations for infantry. FUTURE PLANS: In the future, we will screen samples for serological evidence of infection with Burkholderia pseudomallei, Coxiella burnetii, Ross River virus, SARS-CoV-2 and other operationally relevant pathogens endemic in Australia. Antigenic stimulation assays will be performed on PBMCs collected from seropositive individuals to characterise the immune response to these infections in this healthy American population. BMJ Publishing Group 2021-09-15 /pmc/articles/PMC8444257/ /pubmed/34526342 http://dx.doi.org/10.1136/bmjopen-2021-050330 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Infectious Diseases
Chan-Cuzydlo, Alyssa
Harrison, Dustin J
Pike, Brian L
Currie, Bart J
Mayo, Mark
Salvador, Mark G
Hulsey, William R
Azzarello, Joseph
Ellis, Jeffrey
Kim, Daniel
King-Lewis, William
Smith, Jessica Nicole
Rodriguez, Barbara
Maves, Ryan C
Lawler, James V
Schully, Kevin L
Cohort profile: a migratory cohort study of US Marines who train in Australia
title Cohort profile: a migratory cohort study of US Marines who train in Australia
title_full Cohort profile: a migratory cohort study of US Marines who train in Australia
title_fullStr Cohort profile: a migratory cohort study of US Marines who train in Australia
title_full_unstemmed Cohort profile: a migratory cohort study of US Marines who train in Australia
title_short Cohort profile: a migratory cohort study of US Marines who train in Australia
title_sort cohort profile: a migratory cohort study of us marines who train in australia
topic Infectious Diseases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444257/
https://www.ncbi.nlm.nih.gov/pubmed/34526342
http://dx.doi.org/10.1136/bmjopen-2021-050330
work_keys_str_mv AT chancuzydloalyssa cohortprofileamigratorycohortstudyofusmarineswhotraininaustralia
AT harrisondustinj cohortprofileamigratorycohortstudyofusmarineswhotraininaustralia
AT pikebrianl cohortprofileamigratorycohortstudyofusmarineswhotraininaustralia
AT curriebartj cohortprofileamigratorycohortstudyofusmarineswhotraininaustralia
AT mayomark cohortprofileamigratorycohortstudyofusmarineswhotraininaustralia
AT salvadormarkg cohortprofileamigratorycohortstudyofusmarineswhotraininaustralia
AT hulseywilliamr cohortprofileamigratorycohortstudyofusmarineswhotraininaustralia
AT azzarellojoseph cohortprofileamigratorycohortstudyofusmarineswhotraininaustralia
AT ellisjeffrey cohortprofileamigratorycohortstudyofusmarineswhotraininaustralia
AT kimdaniel cohortprofileamigratorycohortstudyofusmarineswhotraininaustralia
AT kinglewiswilliam cohortprofileamigratorycohortstudyofusmarineswhotraininaustralia
AT smithjessicanicole cohortprofileamigratorycohortstudyofusmarineswhotraininaustralia
AT rodriguezbarbara cohortprofileamigratorycohortstudyofusmarineswhotraininaustralia
AT mavesryanc cohortprofileamigratorycohortstudyofusmarineswhotraininaustralia
AT lawlerjamesv cohortprofileamigratorycohortstudyofusmarineswhotraininaustralia
AT schullykevinl cohortprofileamigratorycohortstudyofusmarineswhotraininaustralia