Cargando…

Functional and behavioral effects of de novo mutations in calcium-related genes in patients with bipolar disorder

Bipolar disorder is a common mental illness occurring in approximately 1% of individuals and requires lifelong treatment. Although genetic factors are known to contribute to this disorder, the genetic architecture has not yet been completely clarified. Our initial trio-based exome sequencing study o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nakamura, Takumi, Nakajima, Kazuo, Kobayashi, Yuki, Itohara, Shigeyoshi, Kasahara, Takaoki, Tsuboi, Takashi, Kato, Tadafumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	General Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444452/ https://www.ncbi.nlm.nih.gov/pubmed/34100076 http://dx.doi.org/10.1093/hmg/ddab152

Ejemplares similares

De novo UNC13B mutation identified in a bipolar disorder patient increases a rare exon‐skipping variant
por: Nakamura, Takumi, et al.
Publicado: (2018)

PS44. Funcional analysis of EHD1, a new candidate gene for bipolar disorder.
por: Nakamura, Takumi, et al.
Publicado: (2016)

Systematic analysis of exonic germline and postzygotic de novo mutations in bipolar disorder
por: Nishioka, Masaki, et al.
Publicado: (2021)

PS71. A Clinical Pilot Study of Plasma Mitochondrial DNA as a Biomarker for Bipolar Disorder
por: Kageyama, Yuki, et al.
Publicado: (2016)

GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice
por: Yamamoto, Hirona, et al.
Publicado: (2023)

Quantitative evaluation of incomplete preweaning lethality in mice by using the CRISPR/Cas9 system
por: Nakamura, Takumi, et al.
Publicado: (2018)

A Marked Effect of Electroconvulsive Stimulation on Behavioral Aberration of Mice with Neuron-Specific Mitochondrial DNA Defects
por: Kasahara, Takaoki, et al.
Publicado: (2008)

Ant1 mutant mice bridge the mitochondrial and serotonergic dysfunctions in bipolar disorder
por: Kato, Tomoaki M., et al.
Publicado: (2018)

Unbiased PCR-free spatio-temporal mapping of the mtDNA mutation spectrum reveals brain region-specific responses to replication instability
por: Bagge, Emilie Kristine, et al.
Publicado: (2020)

Ntrk1 mutation co-segregating with bipolar disorder and inherited kidney disease in a multiplex family causes defects in neuronal growth and depression-like behavior in mice
por: Nakajima, Kazuo, et al.
Publicado: (2020)

Phenethylamine is a substrate of monoamine oxidase B in the paraventricular thalamic nucleus
por: Obata, Youhei, et al.
Publicado: (2022)

Heterozygous Polg mutation causes motor dysfunction due to mtDNA deletions
por: Fuke, Satoshi, et al.
Publicado: (2014)

An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents
por: Zhang, Qi, et al.
Publicado: (2018)

Brain-specific heterozygous loss-of-function of ATP2A2, endoplasmic reticulum Ca(2+) pump responsible for Darier’s disease, causes behavioral abnormalities and a hyper-dopaminergic state
por: Nakajima, Kazuo, et al.
Publicado: (2021)

Plasma Nervonic Acid Is a Potential Biomarker for Major Depressive Disorder: A Pilot Study
por: Kageyama, Yuki, et al.
Publicado: (2017)

Cell-type-specific DNA methylation analysis of the frontal cortices of mutant Polg1 transgenic mice with neuronal accumulation of deleted mitochondrial DNA
por: Sugawara, Hiroko, et al.
Publicado: (2022)

Exome sequencing in the knockin mice generated using the CRISPR/Cas system
por: Nakajima, Kazuo, et al.
Publicado: (2016)

Limb-clasping, cognitive deficit and increased vulnerability to kainic acid-induced seizures in neuronal glycosylphosphatidylinositol deficiency mouse models
por: Kandasamy, Lenin C, et al.
Publicado: (2021)

A diagnostic test to examine early improvement as a predictor of later response to lurasidone in bipolar depression
por: Kishi, Taro, et al.
Publicado: (2023)

Presynaptic dysregulation of the paraventricular thalamic nucleus causes depression-like behavior
por: Kato, Tomoaki M., et al.
Publicado: (2019)

Granuphilin molecularly docks insulin granules to the fusion machinery
por: Gomi, Hiroshi, et al.
Publicado: (2005)

Dendritic Homeostasis Disruption in a Novel Frontotemporal Dementia Mouse Model Expressing Cytoplasmic Fused in Sarcoma
por: Shiihashi, Gen, et al.
Publicado: (2017)

Cortico-amygdala interaction determines the insular cortical neurons involved in taste memory retrieval
por: Abe, Konami, et al.
Publicado: (2020)

Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain
por: Monai, Hiromu, et al.
Publicado: (2016)

Exome sequencing for bipolar disorder points to roles of de novo loss-of-function and protein-altering mutations
por: Kataoka, M, et al.
Publicado: (2016)

Netrin-G1 regulates fear-like and anxiety-like behaviors in dissociable neural circuits
por: Zhang, Qi, et al.
Publicado: (2016)

Familial hypocalciuric hypercalcemia with a de novo heterozygous mutation of calcium-sensing receptor
por: Taki, Katsumi, et al.
Publicado: (2015)

Identification of transcriptional regulatory elements for Ntng1 and Ntng2 genes in mice
por: Yaguchi, Kunio, et al.
Publicado: (2014)

Excitation of prefrontal cortical neurons during conditioning enhances fear memory formation
por: Shibano, Natsumi, et al.
Publicado: (2020)

Supersensitive detection and discrimination of enantiomers by dorsal olfactory receptors: evidence for hierarchical odour coding
por: Sato, Takaaki, et al.
Publicado: (2015)

Involvement of Cyclin-Dependent Kinase-Like 2 in Cognitive Function Required for Contextual and Spatial Learning in Mice
por: Gomi, Hiroshi, et al.
Publicado: (2010)

Fusion of Bipolar Tetraether Lipid Membranes Without Enhanced Leakage of Small Molecules
por: Leriche, Geoffray, et al.
Publicado: (2019)

Mammalian-Specific Central Myelin Protein Opalin Is Redundant for Normal Myelination: Structural and Behavioral Assessments
por: Yoshikawa, Fumio, et al.
Publicado: (2016)

Decreased DNA methylation at promoters and gene-specific neuronal hypermethylation in the prefrontal cortex of patients with bipolar disorder
por: Bundo, Miki, et al.
Publicado: (2021)

De novo CNVs in bipolar affective disorder and schizophrenia
por: Georgieva, Lyudmila, et al.
Publicado: (2014)

De Novo Gene Variants and Familial Bipolar Disorder
por: Toma, Claudio, et al.
Publicado: (2020)

Diversification of behavior and postsynaptic properties by netrin-G presynaptic adhesion family proteins
por: Zhang, Qi, et al.
Publicado: (2016)

Frequency of de novo mutations in Japanese patients with Fabry disease
por: Kobayashi, Masahisa, et al.
Publicado: (2014)

The hippocampus encodes delay and value information during delay-discounting decision making
por: Masuda, Akira, et al.
Publicado: (2020)

Double‐blind, placebo‐controlled study of lurasidone monotherapy for the treatment of bipolar I depression
por: Kato, Tadafumi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_s7f71rh1641t406jh1q1uu4a2r