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A critical assessment of the potential vertical transmission hypotheses: Implications for research on the early-life infection with COVID-19

The risk of potential vertical transmission in SARS-CoV-2 infected pregnant women is currently a topic of debate. To explore the correlation between the two, we searched PubMed, Embase®, and Web of Science for studies on vertical transmission of COVID-19. The quality of the studies was evaluated by...

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Autores principales: Yang, Mengqin, Wang, Qiuqin, Song, Yulei, Zou, Minyan, Li, Yan, Xu, Guihua, Yan, Ting, Bai, Yamei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444478/
https://www.ncbi.nlm.nih.gov/pubmed/34563787
http://dx.doi.org/10.1016/j.placenta.2021.09.005
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author Yang, Mengqin
Wang, Qiuqin
Song, Yulei
Zou, Minyan
Li, Yan
Xu, Guihua
Yan, Ting
Bai, Yamei
author_facet Yang, Mengqin
Wang, Qiuqin
Song, Yulei
Zou, Minyan
Li, Yan
Xu, Guihua
Yan, Ting
Bai, Yamei
author_sort Yang, Mengqin
collection PubMed
description The risk of potential vertical transmission in SARS-CoV-2 infected pregnant women is currently a topic of debate. To explore the correlation between the two, we searched PubMed, Embase®, and Web of Science for studies on vertical transmission of COVID-19. The quality of the studies was evaluated by the Cochrane risk of bias tool. Detailed information of each included case including methods of delivery, protection measures for mothers and neonates at birth, types of specimens, inspection time, results of testing and feeding patterns was collected to assess the possibility of vertical transmission. The results showed that of the 390 neonates reported in 36 studies, 23 were infected with SARS-CoV-2 by potential vertical transmission. From the perspective of virology and pathology, vertical transmission of SARS-CoV-2 was possible via uterus or breastmilk. Some reported potential vertically transmitted neonates could be attributed to horizontal transmission. It is extremely vital to fully elucidate the potential routes of transmission of SARS-CoV-2, implicating clinical practice and nursing to reduce the risk of not only horizontal transmission but also vertical transmission, thus protecting neonates from COVID-19 infection.
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spelling pubmed-84444782021-09-16 A critical assessment of the potential vertical transmission hypotheses: Implications for research on the early-life infection with COVID-19 Yang, Mengqin Wang, Qiuqin Song, Yulei Zou, Minyan Li, Yan Xu, Guihua Yan, Ting Bai, Yamei Placenta Review The risk of potential vertical transmission in SARS-CoV-2 infected pregnant women is currently a topic of debate. To explore the correlation between the two, we searched PubMed, Embase®, and Web of Science for studies on vertical transmission of COVID-19. The quality of the studies was evaluated by the Cochrane risk of bias tool. Detailed information of each included case including methods of delivery, protection measures for mothers and neonates at birth, types of specimens, inspection time, results of testing and feeding patterns was collected to assess the possibility of vertical transmission. The results showed that of the 390 neonates reported in 36 studies, 23 were infected with SARS-CoV-2 by potential vertical transmission. From the perspective of virology and pathology, vertical transmission of SARS-CoV-2 was possible via uterus or breastmilk. Some reported potential vertically transmitted neonates could be attributed to horizontal transmission. It is extremely vital to fully elucidate the potential routes of transmission of SARS-CoV-2, implicating clinical practice and nursing to reduce the risk of not only horizontal transmission but also vertical transmission, thus protecting neonates from COVID-19 infection. Elsevier Ltd. 2021-11 2021-09-16 /pmc/articles/PMC8444478/ /pubmed/34563787 http://dx.doi.org/10.1016/j.placenta.2021.09.005 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Yang, Mengqin
Wang, Qiuqin
Song, Yulei
Zou, Minyan
Li, Yan
Xu, Guihua
Yan, Ting
Bai, Yamei
A critical assessment of the potential vertical transmission hypotheses: Implications for research on the early-life infection with COVID-19
title A critical assessment of the potential vertical transmission hypotheses: Implications for research on the early-life infection with COVID-19
title_full A critical assessment of the potential vertical transmission hypotheses: Implications for research on the early-life infection with COVID-19
title_fullStr A critical assessment of the potential vertical transmission hypotheses: Implications for research on the early-life infection with COVID-19
title_full_unstemmed A critical assessment of the potential vertical transmission hypotheses: Implications for research on the early-life infection with COVID-19
title_short A critical assessment of the potential vertical transmission hypotheses: Implications for research on the early-life infection with COVID-19
title_sort critical assessment of the potential vertical transmission hypotheses: implications for research on the early-life infection with covid-19
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444478/
https://www.ncbi.nlm.nih.gov/pubmed/34563787
http://dx.doi.org/10.1016/j.placenta.2021.09.005
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