S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis

SARS-CoV-2 recognizes, via its spike receptor-binding domain (S-RBD), human angiotensin-converting enzyme 2 (ACE2) to initiate infection. Ecto-domain protein of ACE2 can therefore function as a decoy. Here we show that mutations of S19W, T27W, and N330Y in ACE2 could individually enhance SARS-CoV-2...

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Detalles Bibliográficos
Autores principales: Ye, Fei, Lin, Xi, Chen, Zimin, Yang, Fanli, Lin, Sheng, Yang, Jing, Chen, Hua, Sun, Honglu, Wang, Lingling, Wen, Ao, Zhang, Xindan, Dai, Yushan, Cao, Yu, Yang, Jingyun, Shen, Guobo, Yang, Li, Li, Jiong, Wang, Zhenling, Wang, Wei, Wei, Xiawei, Lu, Guangwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444507/
https://www.ncbi.nlm.nih.gov/pubmed/34531369
http://dx.doi.org/10.1038/s41392-021-00756-4

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