IL-18 binding protein suppresses IL-17-induced osteoclastogenesis and rectifies type 17 helper T cell / regulatory T cell imbalance in rheumatoid arthritis

BACKGROUND: Patients with rheumatoid arthritis (RA) have increased levels of interleukin-18 (IL-18) and decreased levels of IL-18 binding protein (IL-18BP) in the serum and synovial fluid (SF) compared to those in patients with osteoarthritis (OA) or in healthy controls. In this study, we evaluated...

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Detalles Bibliográficos
Autores principales: Min, Hong Ki, Kim, Sehee, Lee, Ji-Yeon, Kim, Kyoung-Woon, Lee, Sang-Heon, Kim, Hae-Rim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444577/
https://www.ncbi.nlm.nih.gov/pubmed/34530864
http://dx.doi.org/10.1186/s12967-021-03071-2

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