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NAD(+) improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway

BACKGROUND: Microglial-mediated neuroinflammation plays an important role in vascular dementia, and modulating neuroinflammation has emerged as a promising treatment target. Nicotinamide adenine dinucleotide (NAD(+)) shows anti-inflammatory and anti-oxidant effects in many neurodegenerative disease...

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Detalles Bibliográficos
Autores principales:	Zhao, Yao, Zhang, Jiawei, Zheng, Yaling, Zhang, Yaxuan, Zhang, Xiao Jie, Wang, Hongmei, Du, Yu, Guan, Jian, Wang, Xiuzhe, Fu, Jianliang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444613/ https://www.ncbi.nlm.nih.gov/pubmed/34530866 http://dx.doi.org/10.1186/s12974-021-02250-8

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