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Evaluation of the Humoral Response to Adeno-Associated Virus-Based Gene Therapy Modalities Using Total Antibody Assays

The number of viral vector-based gene therapies (GTx) continues to grow with two products (Zolgensma® and Luxturna®) approved in the USA as of March 2021. To date, the most commonly used vectors are adeno-associated virus-based (AAV). The pre-existing humoral immunity against AAV (anti-AAV antibodie...

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Detalles Bibliográficos
Autores principales:	Gorovits, Boris, Azadeh, Mitra, Buchlis, George, Harrison, Travis, Havert, Mike, Jawa, Vibha, Long, Brian, McNally, Jim, Milton, Mark, Nelson, Robert, O’Dell, Mark, Richards, Karen, Vettermann, Christian, Wu, Bonnie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2021
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445016/ https://www.ncbi.nlm.nih.gov/pubmed/34529177 http://dx.doi.org/10.1208/s12248-021-00628-3

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