TDP-43 condensation properties specify its RNA-binding and regulatory repertoire

Mutations causing amyotrophic lateral sclerosis (ALS) often affect the condensation properties of RNA-binding proteins (RBPs). However, the role of RBP condensation in the specificity and function of protein-RNA complexes remains unclear. We created a series of TDP-43 C-terminal domain (CTD) variant...

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Detalles Bibliográficos
Autores principales: Hallegger, Martina, Chakrabarti, Anob M., Lee, Flora C.Y., Lee, Bo Lim, Amalietti, Aram G., Odeh, Hana M., Copley, Katie E., Rubien, Jack D., Portz, Bede, Kuret, Klara, Huppertz, Ina, Rau, Frédérique, Patani, Rickie, Fawzi, Nicolas L., Shorter, James, Luscombe, Nicholas M., Ule, Jernej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445024/
https://www.ncbi.nlm.nih.gov/pubmed/34380047
http://dx.doi.org/10.1016/j.cell.2021.07.018

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