Strategic Variants of CSP Delivered as SynDNA Vaccines Demonstrate Heterogeneity of Immunogenicity and Protection from Plasmodium Infection in a Murine Model

Malaria infects millions of people every year, and despite recent advances in controlling disease spread, such as vaccination, it remains a global health concern. The circumsporozoite protein (CSP) has long been acknowledged as a key target in antimalarial immunity. Leveraging the DNA vaccine platfo...

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Detalles Bibliográficos
Autores principales: Reeder, Sophia M., Bah, Mamadou A., Tursi, Nicholas J., Brooks, Rebekah C., Patel, Ami, Esquivel, Rianne, Eaton, Alison, Jhun, Hugo, Chu, Jacqueline, Kim, Kevin, Xu, Ziyang, Zavala, Fidel, Weiner, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Microbial Immunity and Vaccines
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445182/
https://www.ncbi.nlm.nih.gov/pubmed/34152830
http://dx.doi.org/10.1128/IAI.00728-20

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