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Evolutionary and functional lessons from human-specific amino acid substitution matrices
Human genetic variation in coding regions is fundamental to the study of protein structure and function. Most methods for interpreting missense variants consider substitution measures derived from homologous proteins across different species. In this study, we introduce human-specific amino acid (AA...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445205/ https://www.ncbi.nlm.nih.gov/pubmed/34541526 http://dx.doi.org/10.1093/nargab/lqab079 |