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Ongoing habenular activity is driven by forebrain networks and modulated by olfactory stimuli

Ongoing neural activity, which represents internal brain states, is constantly modulated by the sensory information that is generated by the environment. In this study, we show that the habenular circuits act as a major brain hub integrating the structured ongoing activity of the limbic forebrain ci...

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Detalles Bibliográficos
Autores principales: Bartoszek, Ewelina Magdalena, Ostenrath, Anna Maria, Jetti, Suresh Kumar, Serneels, Bram, Mutlu, Aytac Kadir, Chau, Khac Thanh Phong, Yaksi, Emre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445323/
https://www.ncbi.nlm.nih.gov/pubmed/34416179
http://dx.doi.org/10.1016/j.cub.2021.08.021
Descripción
Sumario:Ongoing neural activity, which represents internal brain states, is constantly modulated by the sensory information that is generated by the environment. In this study, we show that the habenular circuits act as a major brain hub integrating the structured ongoing activity of the limbic forebrain circuitry and the olfactory information. We demonstrate that ancestral homologs of amygdala and hippocampus in zebrafish forebrain are the major drivers of ongoing habenular activity. We also reveal that odor stimuli can modulate the activity of specific habenular neurons that are driven by this forebrain circuitry. Our results highlight a major role for the olfactory system in regulating the ongoing activity of the habenula and the forebrain, thereby altering brain’s internal states.