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Ongoing habenular activity is driven by forebrain networks and modulated by olfactory stimuli

Ongoing neural activity, which represents internal brain states, is constantly modulated by the sensory information that is generated by the environment. In this study, we show that the habenular circuits act as a major brain hub integrating the structured ongoing activity of the limbic forebrain ci...

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Autores principales: Bartoszek, Ewelina Magdalena, Ostenrath, Anna Maria, Jetti, Suresh Kumar, Serneels, Bram, Mutlu, Aytac Kadir, Chau, Khac Thanh Phong, Yaksi, Emre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445323/
https://www.ncbi.nlm.nih.gov/pubmed/34416179
http://dx.doi.org/10.1016/j.cub.2021.08.021
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author Bartoszek, Ewelina Magdalena
Ostenrath, Anna Maria
Jetti, Suresh Kumar
Serneels, Bram
Mutlu, Aytac Kadir
Chau, Khac Thanh Phong
Yaksi, Emre
author_facet Bartoszek, Ewelina Magdalena
Ostenrath, Anna Maria
Jetti, Suresh Kumar
Serneels, Bram
Mutlu, Aytac Kadir
Chau, Khac Thanh Phong
Yaksi, Emre
author_sort Bartoszek, Ewelina Magdalena
collection PubMed
description Ongoing neural activity, which represents internal brain states, is constantly modulated by the sensory information that is generated by the environment. In this study, we show that the habenular circuits act as a major brain hub integrating the structured ongoing activity of the limbic forebrain circuitry and the olfactory information. We demonstrate that ancestral homologs of amygdala and hippocampus in zebrafish forebrain are the major drivers of ongoing habenular activity. We also reveal that odor stimuli can modulate the activity of specific habenular neurons that are driven by this forebrain circuitry. Our results highlight a major role for the olfactory system in regulating the ongoing activity of the habenula and the forebrain, thereby altering brain’s internal states.
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spelling pubmed-84453232021-09-22 Ongoing habenular activity is driven by forebrain networks and modulated by olfactory stimuli Bartoszek, Ewelina Magdalena Ostenrath, Anna Maria Jetti, Suresh Kumar Serneels, Bram Mutlu, Aytac Kadir Chau, Khac Thanh Phong Yaksi, Emre Curr Biol Article Ongoing neural activity, which represents internal brain states, is constantly modulated by the sensory information that is generated by the environment. In this study, we show that the habenular circuits act as a major brain hub integrating the structured ongoing activity of the limbic forebrain circuitry and the olfactory information. We demonstrate that ancestral homologs of amygdala and hippocampus in zebrafish forebrain are the major drivers of ongoing habenular activity. We also reveal that odor stimuli can modulate the activity of specific habenular neurons that are driven by this forebrain circuitry. Our results highlight a major role for the olfactory system in regulating the ongoing activity of the habenula and the forebrain, thereby altering brain’s internal states. Cell Press 2021-09-13 /pmc/articles/PMC8445323/ /pubmed/34416179 http://dx.doi.org/10.1016/j.cub.2021.08.021 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Bartoszek, Ewelina Magdalena
Ostenrath, Anna Maria
Jetti, Suresh Kumar
Serneels, Bram
Mutlu, Aytac Kadir
Chau, Khac Thanh Phong
Yaksi, Emre
Ongoing habenular activity is driven by forebrain networks and modulated by olfactory stimuli
title Ongoing habenular activity is driven by forebrain networks and modulated by olfactory stimuli
title_full Ongoing habenular activity is driven by forebrain networks and modulated by olfactory stimuli
title_fullStr Ongoing habenular activity is driven by forebrain networks and modulated by olfactory stimuli
title_full_unstemmed Ongoing habenular activity is driven by forebrain networks and modulated by olfactory stimuli
title_short Ongoing habenular activity is driven by forebrain networks and modulated by olfactory stimuli
title_sort ongoing habenular activity is driven by forebrain networks and modulated by olfactory stimuli
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445323/
https://www.ncbi.nlm.nih.gov/pubmed/34416179
http://dx.doi.org/10.1016/j.cub.2021.08.021
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