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Functional in vitro assessment of modified antibodies: Impact of label on protein properties
Labelling of therapeutic antibodies with radionuclides or fluorophores is routinely used to study their pharmacokinetic properties. A critical assumption in utilizing labelled therapeutic antibodies is that the label has no unfavourable effects on antibody charge, hydrophobicity, or receptor affinit...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445452/ https://www.ncbi.nlm.nih.gov/pubmed/34529712 http://dx.doi.org/10.1371/journal.pone.0257342 |