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Mild phenotype of knockouts of the major apurinic/apyrimidinic endonuclease APEX1 in a non-cancer human cell line

The major human apurinic/apyrimidinic (AP) site endonuclease, APEX1, is a central player in the base excision DNA repair (BER) pathway and has a role in the regulation of DNA binding by transcription factors. In vertebrates, APEX1 knockouts are embryonic lethal, and only a handful of knockout cell l...

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Detalles Bibliográficos
Autores principales:	Kim, Daria V., Kulishova, Liliya M., Torgasheva, Natalia A., Melentyev, Vasily S., Dianov, Grigory L., Medvedev, Sergey P., Zakian, Suren M., Zharkov, Dmitry O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445474/ https://www.ncbi.nlm.nih.gov/pubmed/34529719 http://dx.doi.org/10.1371/journal.pone.0257473

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