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Mesenchymal stromal cell aging impairs the self-organizing capacity of lung alveolar epithelial stem cells
Multicellular organisms maintain structure and function of tissues/organs through emergent, self-organizing behavior. In this report, we demonstrate a critical role for lung mesenchymal stromal cell (L-MSC) aging in determining the capacity to form three-dimensional organoids or ‘alveolospheres’ wit...
Autores principales: | Chanda, Diptiman, Rehan, Mohammad, Smith, Samuel R, Dsouza, Kevin G, Wang, Yong, Bernard, Karen, Kurundkar, Deepali, Memula, Vinayak, Kojima, Kyoko, Mobley, James A, Benavides, Gloria A, Darley-Usmar, Victor, Kim, Young-iL, Zmijewski, Jaroslaw W, Deshane, Jessy S, De Langhe, Stijn, Thannickal, Victor J |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445616/ https://www.ncbi.nlm.nih.gov/pubmed/34528872 http://dx.doi.org/10.7554/eLife.68049 |
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