KIF20B Promotes Cell Proliferation and May Be a Potential Therapeutic Target in Pancreatic Cancer

KIFs have been reported to play a critical role in a variety of tumors, and KIF20B is a protein in KFIs. In this research, KIF20B was highly expressed in the GEO database and our hospital's data, and high expression of KIF20B suggested poor prognosis. We detect the expression of KIF20B in pancr...

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Autores principales: Chen, Jing, Zhao, Cui-Cui, Chen, Fei-Ran, Feng, Guo-Wei, Luo, Fei, Jiang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445734/
https://www.ncbi.nlm.nih.gov/pubmed/34539784
http://dx.doi.org/10.1155/2021/5572402
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author Chen, Jing
Zhao, Cui-Cui
Chen, Fei-Ran
Feng, Guo-Wei
Luo, Fei
Jiang, Tao
author_facet Chen, Jing
Zhao, Cui-Cui
Chen, Fei-Ran
Feng, Guo-Wei
Luo, Fei
Jiang, Tao
author_sort Chen, Jing
collection PubMed
description KIFs have been reported to play a critical role in a variety of tumors, and KIF20B is a protein in KFIs. In this research, KIF20B was highly expressed in the GEO database and our hospital's data, and high expression of KIF20B suggested poor prognosis. We detect the expression of KIF20B in pancreatic cancer and adjacent normal tissues using immunohistochemistry. Knockdown of KIF20B in pancreatic cancer cell lines, PANC-1 and BxPC-3 cells, inhibited cell proliferation which are detected by colony formation assays, CCK8, and western bolt of Ki-67 and PCNA. Xenograft assay showed a similar result in vivo. KIF20B is a potential therapeutic target in pancreatic cancer.
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spelling pubmed-84457342021-09-17 KIF20B Promotes Cell Proliferation and May Be a Potential Therapeutic Target in Pancreatic Cancer Chen, Jing Zhao, Cui-Cui Chen, Fei-Ran Feng, Guo-Wei Luo, Fei Jiang, Tao J Oncol Research Article KIFs have been reported to play a critical role in a variety of tumors, and KIF20B is a protein in KFIs. In this research, KIF20B was highly expressed in the GEO database and our hospital's data, and high expression of KIF20B suggested poor prognosis. We detect the expression of KIF20B in pancreatic cancer and adjacent normal tissues using immunohistochemistry. Knockdown of KIF20B in pancreatic cancer cell lines, PANC-1 and BxPC-3 cells, inhibited cell proliferation which are detected by colony formation assays, CCK8, and western bolt of Ki-67 and PCNA. Xenograft assay showed a similar result in vivo. KIF20B is a potential therapeutic target in pancreatic cancer. Hindawi 2021-09-09 /pmc/articles/PMC8445734/ /pubmed/34539784 http://dx.doi.org/10.1155/2021/5572402 Text en Copyright © 2021 Jing Chen et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chen, Jing
Zhao, Cui-Cui
Chen, Fei-Ran
Feng, Guo-Wei
Luo, Fei
Jiang, Tao
KIF20B Promotes Cell Proliferation and May Be a Potential Therapeutic Target in Pancreatic Cancer
title KIF20B Promotes Cell Proliferation and May Be a Potential Therapeutic Target in Pancreatic Cancer
title_full KIF20B Promotes Cell Proliferation and May Be a Potential Therapeutic Target in Pancreatic Cancer
title_fullStr KIF20B Promotes Cell Proliferation and May Be a Potential Therapeutic Target in Pancreatic Cancer
title_full_unstemmed KIF20B Promotes Cell Proliferation and May Be a Potential Therapeutic Target in Pancreatic Cancer
title_short KIF20B Promotes Cell Proliferation and May Be a Potential Therapeutic Target in Pancreatic Cancer
title_sort kif20b promotes cell proliferation and may be a potential therapeutic target in pancreatic cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445734/
https://www.ncbi.nlm.nih.gov/pubmed/34539784
http://dx.doi.org/10.1155/2021/5572402
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