Fermitin family member 2 promotes melanoma progression by enhancing the binding of p-α-Pix to Rac1 to activate the MAPK pathway

We identified fermitin family member 2 (FERMT2, also known as kindlin-2) as a potential target in A375 cell line by siRNA library screening. Drugs that target mutant BRAF kinase lack durable efficacy in the treatment of melanoma because of acquired resistance, thus the identification of novel therap...

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Detalles Bibliográficos
Autores principales: Huang, Shaobin, Deng, Wuguo, Wang, Peng, Yan, Yue, Xie, Chuanbo, Cao, Xiaoling, Chen, Miao, Zhang, Changlin, Shi, Dingbo, Dong, Yunxian, Cheng, Pu, Xu, Hailin, Zhu, Wenkai, Hu, Zhicheng, Tang, Bing, Zhu, Jiayuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445820/
https://www.ncbi.nlm.nih.gov/pubmed/34321603
http://dx.doi.org/10.1038/s41388-021-01954-8

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