Cargando…

SSC-ILD mouse model induced by osmotic minipump delivered bleomycin: effect of Nintedanib

Systemic sclerosis (SSc) is an autoimmune disease characterized by an excessive production and accumulation of collagen in the skin and internal organs often associated with interstitial lung disease (ILD). Its pathogenetic mechanisms are unknown and the lack of animal models mimicking the features...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ravanetti, Francesca, Ferrini, Erica, Ragionieri, Luisa, Khalajzeyqami, Zahra, Nicastro, Maria, Ridwan, Yanto, Kleinjan, Alex, Villetti, Gino, Grandi, Andrea, Stellari, Franco Fabio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445948/ https://www.ncbi.nlm.nih.gov/pubmed/34531421 http://dx.doi.org/10.1038/s41598-021-97728-z

Ejemplares similares

Modeling pulmonary fibrosis through bleomycin delivered by osmotic minipump: a new histomorphometric method of evaluation
por: Ravanetti, Francesca, et al.
Publicado: (2020)

Indocyanine-enhanced mouse model of bleomycin-induced lung fibrosis with hallmarks of progressive emphysema
por: Grandi, Andrea, et al.
Publicado: (2023)

Longitudinal assessment of bleomycin-induced lung fibrosis by Micro-CT correlates with histological evaluation in mice
por: Ruscitti, Francesca, et al.
Publicado: (2017)

Pivotal role of micro-CT technology in setting up an optimized lung fibrosis mouse model for drug screening
por: Khalajzeyqami, Zahra, et al.
Publicado: (2022)

Proteomic Fingerprint of Lung Fibrosis Progression and Response to Therapy in Bleomycin-Induced Mouse Model
por: Principi, Lucrezia, et al.
Publicado: (2023)

In-vivo lung fibrosis staging in a bleomycin-mouse model: a new micro-CT guided densitometric approach
por: Mecozzi, Laura, et al.
Publicado: (2020)

The rapid hydrolysis of chlordiazepoxide to demoxepam may affect the outcome of chronic osmotic minipump studies
por: Vinkers, Christiaan H., et al.
Publicado: (2010)

Alfaxalone and Dexmedetomidine as an Alternative to Gas Anesthesia for Micro-CT Lung Imaging in a Bleomycin-Induced Pulmonary Fibrosis Murine Model
por: Ferrini, Erica, et al.
Publicado: (2020)

Heterologous Matrix Metalloproteinase Gene Promoter Activity Allows In Vivo Real-time Imaging of Bleomycin-Induced Lung Fibrosis in Transiently Transgenized Mice
por: Stellari, Fabio Franco, et al.
Publicado: (2017)

Quantification of Lung Fibrosis in IPF-Like Mouse Model and Pharmacological Response to Treatment by Micro-Computed Tomography
por: Ruscitti, Francesca, et al.
Publicado: (2020)

Interstitial lung disease associated with systemic sclerosis (SSc-ILD)
por: Cottin, Vincent, et al.
Publicado: (2019)

Natural variability in the disease course of SSc-ILD: implications for treatment
por: Vonk, Madelon C., et al.
Publicado: (2021)

A new nucleosomic-based model to identify and diagnose SSc-ILD
por: Guiot, Julien, et al.
Publicado: (2020)

Identifying unmet needs in SSc-ILD by semi-qualitative in-depth interviews
por: Hoffmann-Vold, Anna-Maria, et al.
Publicado: (2021)

Cost-Effectiveness of Nintedanib for Patients with Progressive Fibrosing Interstitial Lung Disease (PF-ILD)
por: Westerink, Lotte, et al.
Publicado: (2022)

The need for a holistic approach for SSc-ILD – achievements and ambiguity in a devastating disease
por: Hoffmann-Vold, Anna-Maria, et al.
Publicado: (2020)

High-Resolution Computed Tomography: Lights and Shadows in Improving Care for SSc-ILD Patients
por: Ruaro, Barbara, et al.
Publicado: (2021)

Exploring the common pathophysiological links between IPF, SSc-ILD and post-COVID fibrosis
por: Swarnakar, Rajesh, et al.
Publicado: (2022)

Influence of CT Image Matrix Size and Kernel Type on the Assessment of HRCT in Patients with SSC-ILD
por: Balmer, Bettina D., et al.
Publicado: (2022)

Nintedanib treatment for bleomycin-induced lung injury - First report
por: Rnjak, Dina, et al.
Publicado: (2023)

Mediators of systemic sclerosis-associated interstitial lung disease (SSc-ILD): systematic review and meta-analyses
por: Fields, Aislin, et al.
Publicado: (2023)

A fully automated micro‑CT deep learning approach for precision preclinical investigation of lung fibrosis progression and response to therapy
por: Buccardi, Martina, et al.
Publicado: (2023)

CD4(+)LAG3(+)T cells are decreased in SSc-ILD and affect fibroblast mesenchymal transition by TGF-β3
por: Qin, Linmang, et al.
Publicado: (2023)

Persistency of Mesenchymal Stromal/Stem Cells in Lungs
por: Ferrini, Erica, et al.
Publicado: (2021)

In vivo monitoring of lung inflammation in CFTR-deficient mice
por: Stellari, Fabio, et al.
Publicado: (2016)

Nintedanib Reduces Neutrophil Chemotaxis via Activating GRK2 in Bleomycin-Induced Pulmonary Fibrosis
por: Chen, Wei-Chih, et al.
Publicado: (2020)

Cyclophosphamide versus mycophenolate mofetil in scleroderma interstitial lung disease (SSc-ILD) as induction therapy: a single-centre, retrospective analysis
por: Shenoy, Padmanabha D., et al.
Publicado: (2016)

Efficacy and Safety of Nintedanib in Patients with Connective Tissue Disease-Interstitial Lung Disease (CTD-ILD): A Real-World Single Center Experience
por: Boutel, Maria, et al.
Publicado: (2023)

Chronic Methylglyoxal Infusion by Minipump Causes Pancreatic β-Cell Dysfunction and Induces Type 2 Diabetes in Sprague-Dawley Rats
por: Dhar, Arti, et al.
Publicado: (2011)

Impact of lung function decline on time to hospitalisation events in systemic sclerosis-associated interstitial lung disease (SSc-ILD): a joint model analysis
por: Kreuter, Michael, et al.
Publicado: (2022)

The PH‐ILD Detection tool: External validation and use in patients with ILD
por: Parikh, Raj, et al.
Publicado: (2023)

Design of the PF-ILD trial: a double-blind, randomised, placebo-controlled phase III trial of nintedanib in patients with progressive fibrosing interstitial lung disease
por: Flaherty, Kevin R, et al.
Publicado: (2017)

Nintedanib reduces ventilation‐augmented bleomycin‐induced epithelial–mesenchymal transition and lung fibrosis through suppression of the Src pathway
por: Li, Li‐Fu, et al.
Publicado: (2017)

Nintedanib Inhibits Endothelial Mesenchymal Transition in Bleomycin-Induced Pulmonary Fibrosis via Focal Adhesion Kinase Activity Reduction
por: Yu, Wen-Kuang, et al.
Publicado: (2022)

Tracking Validation of ILD
por: Lu, S.
Publicado: (2018)

ILD simulation model
por: Lu, S.
Publicado: (2018)

In Vivo Imaging of Transiently Transgenized Mice with a Bovine Interleukin 8 (CXCL8) Promoter/Luciferase Reporter Construct
por: Stellari, Fabio Franco, et al.
Publicado: (2012)

Monitoring inflammation and airway remodeling by fluorescence molecular tomography in a chronic asthma model
por: Stellari, Fabio, et al.
Publicado: (2015)

Interstitial Lung Disease in Patients With Systemic Sclerosis: Toward Personalized-Medicine-Based Prediction and Drug Screening Models of Systemic Sclerosis-Related Interstitial Lung Disease (SSc-ILD)
por: Khedoe, Padmini, et al.
Publicado: (2020)

The design of the ILD forward region
por: Levy, A
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_5ic31quqv9r18p2cui9hg55r9o