Pediatric MDS and bone marrow failure-associated germline mutations in SAMD9 and SAMD9L impair multiple pathways in primary hematopoietic cells

Pediatric myelodysplastic syndromes (MDS) are a heterogeneous disease group associated with impaired hematopoiesis, bone marrow hypocellularity, and frequently have deletions involving chromosome 7 (monosomy 7). We and others recently identified heterozygous germline mutations in SAMD9 and SAMD9L in...

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Detalles Bibliográficos
Autores principales: Thomas, Melvin E., Abdelhamed, Sherif, Hiltenbrand, Ryan, Schwartz, Jason R., Sakurada, Sadie Miki, Walsh, Michael, Song, Guangchun, Ma, Jing, Pruett-Miller, Shondra M., Klco, Jeffery M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446103/
https://www.ncbi.nlm.nih.gov/pubmed/33731850
http://dx.doi.org/10.1038/s41375-021-01212-6

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