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Normobaric oxygen may correct chronic cerebral ischemia‐mediated EEG anomalies
AIMS: To explore the safety and efficacy of normobaric oxygen (NBO) on correcting chronic cerebral ischemia (CCI) and related EEG anomalies. METHODS: This prospective randomized trial (NCT03745092) enrolled 50 cases of CCI patients, which were divided into NBO (8 L/min of oxygen supplement) group an...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446210/ https://www.ncbi.nlm.nih.gov/pubmed/34242498 http://dx.doi.org/10.1111/cns.13703 |
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author | Ding, Jia‐Yue Liu, Yu Rajah, Gary‐B. Chen, Zhi‐Ying Zhang, Shi‐Yong Ding, Yu‐Chuan Ji, Xun‐Ming Meng, Ran |
author_facet | Ding, Jia‐Yue Liu, Yu Rajah, Gary‐B. Chen, Zhi‐Ying Zhang, Shi‐Yong Ding, Yu‐Chuan Ji, Xun‐Ming Meng, Ran |
author_sort | Ding, Jia‐Yue |
collection | PubMed |
description | AIMS: To explore the safety and efficacy of normobaric oxygen (NBO) on correcting chronic cerebral ischemia (CCI) and related EEG anomalies. METHODS: This prospective randomized trial (NCT03745092) enrolled 50 cases of CCI patients, which were divided into NBO (8 L/min of oxygen supplement) group and control group (room air) randomly, and also enrolled 21 healthy volunteers. Two times of 30‐min EEG recordings with the interval of 45min of NBO or room air were analyzed quantitatively. RESULTS: The CCI‐mediated EEG presented with two patterns of electrical activities: high‐power oscillations (high‐power EEG, n = 26) and paroxysmal slow activities under the normal‐power background (normal‐power EEG, n = 24). The fronto‐central absolute power (AP) of the beta, alpha, theta, and delta in the high‐power EEG was higher than that in healthy EEG (p < 0.05). The fronto‐central theta/alpha, delta/alpha and (delta + theta)/(alpha + beta) ratios in the normal‐power EEG were higher than those in healthy EEG (p < 0.05). The high‐power EEG in NBO group had higher fronto‐central AP reduction rates than those in control group (p < 0.05). NBO remarkably reduced the fronto‐central theta/alpha, delta/alpha, and (delta + theta)/(alpha + beta) ratios in the normal‐power EEG (p < 0.05). CONCLUSIONS: NBO rapidly ameliorates CCI‐mediated EEG anomalies, including attenuation of the abnormal high‐power oscillations and the paroxysmal slow activities associated with CCI. |
format | Online Article Text |
id | pubmed-8446210 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84462102021-09-22 Normobaric oxygen may correct chronic cerebral ischemia‐mediated EEG anomalies Ding, Jia‐Yue Liu, Yu Rajah, Gary‐B. Chen, Zhi‐Ying Zhang, Shi‐Yong Ding, Yu‐Chuan Ji, Xun‐Ming Meng, Ran CNS Neurosci Ther Original Articles AIMS: To explore the safety and efficacy of normobaric oxygen (NBO) on correcting chronic cerebral ischemia (CCI) and related EEG anomalies. METHODS: This prospective randomized trial (NCT03745092) enrolled 50 cases of CCI patients, which were divided into NBO (8 L/min of oxygen supplement) group and control group (room air) randomly, and also enrolled 21 healthy volunteers. Two times of 30‐min EEG recordings with the interval of 45min of NBO or room air were analyzed quantitatively. RESULTS: The CCI‐mediated EEG presented with two patterns of electrical activities: high‐power oscillations (high‐power EEG, n = 26) and paroxysmal slow activities under the normal‐power background (normal‐power EEG, n = 24). The fronto‐central absolute power (AP) of the beta, alpha, theta, and delta in the high‐power EEG was higher than that in healthy EEG (p < 0.05). The fronto‐central theta/alpha, delta/alpha and (delta + theta)/(alpha + beta) ratios in the normal‐power EEG were higher than those in healthy EEG (p < 0.05). The high‐power EEG in NBO group had higher fronto‐central AP reduction rates than those in control group (p < 0.05). NBO remarkably reduced the fronto‐central theta/alpha, delta/alpha, and (delta + theta)/(alpha + beta) ratios in the normal‐power EEG (p < 0.05). CONCLUSIONS: NBO rapidly ameliorates CCI‐mediated EEG anomalies, including attenuation of the abnormal high‐power oscillations and the paroxysmal slow activities associated with CCI. John Wiley and Sons Inc. 2021-07-09 /pmc/articles/PMC8446210/ /pubmed/34242498 http://dx.doi.org/10.1111/cns.13703 Text en © 2021 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Ding, Jia‐Yue Liu, Yu Rajah, Gary‐B. Chen, Zhi‐Ying Zhang, Shi‐Yong Ding, Yu‐Chuan Ji, Xun‐Ming Meng, Ran Normobaric oxygen may correct chronic cerebral ischemia‐mediated EEG anomalies |
title | Normobaric oxygen may correct chronic cerebral ischemia‐mediated EEG anomalies |
title_full | Normobaric oxygen may correct chronic cerebral ischemia‐mediated EEG anomalies |
title_fullStr | Normobaric oxygen may correct chronic cerebral ischemia‐mediated EEG anomalies |
title_full_unstemmed | Normobaric oxygen may correct chronic cerebral ischemia‐mediated EEG anomalies |
title_short | Normobaric oxygen may correct chronic cerebral ischemia‐mediated EEG anomalies |
title_sort | normobaric oxygen may correct chronic cerebral ischemia‐mediated eeg anomalies |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446210/ https://www.ncbi.nlm.nih.gov/pubmed/34242498 http://dx.doi.org/10.1111/cns.13703 |
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