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Lysine Methyltransferase Inhibitors Impair H4K20me2 and 53BP1 Foci in Response to DNA Damage in Sarcomas, a Synthetic Lethality Strategy

BACKGROUND: Chromatin is dynamically remodeled to adapt to all DNA-related processes, including DNA damage responses (DDR). This adaptation requires DNA and histone epigenetic modifications, which are mediated by several types of enzymes; among them are lysine methyltransferases (KMTs). METHODS: KMT...

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Detalles Bibliográficos
Autores principales:	Campillo-Marcos, Ignacio, Monte-Serrano, Eva, Navarro-Carrasco, Elena, García-González, Raúl, Lazo, Pedro A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446283/ https://www.ncbi.nlm.nih.gov/pubmed/34540832 http://dx.doi.org/10.3389/fcell.2021.715126

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