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Augmenting and directing long-range CRISPR-mediated activation in human cells

Epigenetic editing is an emerging technology that uses artificial transcription factors (aTFs) to regulate expression of a target gene. Although human genes can be robustly upregulated by targeting aTFs to promoters, the activation induced by directing aTFs to distal transcriptional enhancers is sub...

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Detalles Bibliográficos
Autores principales:	Tak, Y. Esther, Horng, Joy E., Perry, Nicholas T., Schultz, Hayley T., Iyer, Sowmya, Yao, Qiuming, Zou, Luli S., Aryee, Martin J., Pinello, Luca, Joung, J. Keith
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446310/ https://www.ncbi.nlm.nih.gov/pubmed/34354266 http://dx.doi.org/10.1038/s41592-021-01224-1

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